Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Correlation of Adiponectin With Testosterone in Patients With and Without Type 2 Diabetes and Erectile Dysfunction. 30339037 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Odds ratio showed that lower levels of adiponectin and higher levels of resistin, but not of other cytokines, increased the risk of developing type 2 diabetes mellitus. 31811995 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE In this 10-year prospective study, NGT with higher serum RBP4 and PAI-1, and with lower adiponectin were associated with new-onset prediabetes and type 2 diabetes. 31690939 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Plasma levels of Ad are reduced in obesity, which contributes to type 2 diabetes. 31629112 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE This suggests that treatment of adiponectin effectively improves testicular functions by increasing expression of insulin receptor-mediated increased transport of energy substrate (glucose and lactate) and a marked reduction in oxidative stress are the possible mechanism by which adiponectin effectively improves testicular function in T2D mice. 31676315 2020
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE This study aimed to investigate gene-environment interactions among moderate/severe periodontitis, polymorphisms of adiponectin (ADIPOQ)-rs1501299, and leptin receptor (LEPR)-rs1137100 on T2DM risk in Chinese subjects. 31128439 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Scoring of peripheral vascular calcification and peripheral arterial occlusive disease, using CT-scan and color-duplex ultrasonography respectively, were conducted and explored in relation to serum adiponectin level in a cross sectional study of 197 patients with type 2 diabetes. 31168327 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Further research is required to elucidate the role of adiponectin in the development and/or progression of microvascular disease in T2DM patients. 29308741 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The biomarker score that comprised of four biomarkers (TG-to-HDL ratio, ALT, ferritin, and adiponectin) was positively associated with T2DM risk (<i>P</i> trend <0.001). 31769241 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The results of the meta-analysis did not show significant differences (<i>p</i> > 0.05) between low GI and higher GI diets with respect to adiponectin and C-reactive proteins in patients with type 2 diabetes, but a significant difference (<i>p</i> < 0.001) was observed between the two groups in relation to interleukin-6. 31336986 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Association between the -11377 C/G and -11391 G/A polymorphisms of adiponectin gene and adiponectin levels with susceptibility to type 1 and type 2 diabetes mellitus in population from the west of Iran, correlation with lipid profile. 30203461 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE There was a positive association between blood adiponectin and ALMBMI in postmenopausal women without T2DM, but no association in those with T2DM. 31688578 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Polymorphisms in the <i>ADIPOQ</i> gene are known to influence an individual's predisposition to metabolic syndrome and type 2 diabetes. 30863757 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE There was a positive association between blood adiponectin and ALMBMI in postmenopausal women without T2DM, but no association in those with T2DM. 31461078 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Adiponectin was inversely associated with incident type 2 diabetes. 30599058 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE We hypothesized that the reliance of the healthy females' hearts on augmented adiponectin (APN)-connexin 43 (Cx43) signaling becomes paradoxically detrimental when disrupted by T2DM in an E<sub>2</sub>-dependent manner. 30523063 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Future studies can use these methods to examine insulin, adiponectin, and leptin metabolic dysregulation in aging and disease states, such as type 2 diabetes and Alzheimer's disease-related dementias. 31539648 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE The aim of this study was to evaluate adiponectin and 8-OHdG amongst elderly patients with T2DM and to determine the role of adiponectin and 8-OHdG in the cognitive impairment of the elderly patients with T2DM. 31424368 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE Subgroup analysis showed that both rs266729 and rs17300539 of ADIPOQ were associated with the risk of T2D in Caucasian population, but only rs266729 of ADIPOQ in Asian population and rs2144908 in other population including multinational North American. 30860284 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Male gender and history of both gestational and type 2 diabetes were associated with significantly lower total adiponectin levels (p < 0.05). 31159801 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE The adipokines DPP-4 and leptin in the serum can influence the body fat distribution of patients with T2MD; there is an important association of DPP-4, leptin and ADPN levels with MS, which may be used as therapeutic targets for multiple metabolism disorders of T2MD. 29205013 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 GeneticVariation disease BEFREE The recessive model of the ADIPOQ polymorphism rs822396 was significantly shown to confer a 3.63-fold risk towards type 2 diabetes after adjusting for confounding factors and Bonferroni correction [odds ratio (OR): 3.63 (1.20-10.96), p = 0.022]. rs1501299 gave a 3.82-fold risk towards development of T2DM but was not statistically significant after Bonferroni correction [OR: 3.82 (1.16-12.55), p = 0.027]. 31755094 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE We assessed if there is a difference in IR and metabolic syndrome components between glimepiride and glibenclamide treatment as well as adiponectin concentration in T2DM. 31292311 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 Biomarker disease BEFREE Taken together, adiponectin reversed the effects of insulin resistance via AMPK α1, which provides a novel insight into the protective mechanism of adiponectin and may be used as a new strategy for the treatment of type 2 diabetes. 31693217 2019
Diabetes Mellitus, Non-Insulin-Dependent
0.600 AlteredExpression disease BEFREE Ten randomized controlled trials (RCTs), that evaluated the effects of SGLT2 inhibitors on blood leptin and adiponectin levels in patients with type 2 diabetes, were identified by performing a systematic search of Pubmed, Embase, Cochrane, and Web of science databases through July 2018. 31408894 2019