|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Moreover, it exhibited pharmacological activities against hyperlipidemia, obesity, and hyperglycemia as well as appetite.These biological actions of <i>A. orientale</i> might contribute to adiponectin activation or a role as a farnesoid X receptor agonist.
|
31275407 |
2019 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
In obese mice the expression of exogenous BP3 reduced hyperglycemia, hepatosteatosis and weight gain, blunted de novo lipogenesis in liver and adipose tissues, increased circulating adiponectin and decreased NEFA.
|
30374109 |
2018 |
|
Hyperglycemia
|
0.400 |
Therapeutic
|
disease |
CTD_human |
A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms.
|
29991592 |
2018 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We here examined whether hyperglycemia and low adiponectin (APN) levels delayed normal retinal vascularization, driven primarily by dysregulated photoreceptor metabolism.
|
29180355 |
2018 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The present study demonstrated that HS intake ameliorated hyperglycemia and insulin resistance in WBKDF rats, which may be due to increased plasma levels of adiponectin.
|
29744365 |
2018 |
|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin.
|
29912982 |
2018 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
To investigate long-term consequences of diabetes during pregnancy, we determined adiponectin and leptin levels in adolescents born by women with type 1 diabetic (T1D) or non-diabetic mothers, and determined associations between adiponectin and leptin levels in adolescence and the magnitude of intrauterine hyperglycemia.
|
28641783 |
2017 |
|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
A genome-wide association study was conducted in 1,322 pregnant women from the Hyperglycemia and Adverse Pregnancy Outcome Study with adiponectin measured at ∼28 weeks of gestation.
|
28317342 |
2017 |
|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Importantly, reduced expression of Thrap3 in fat tissue by antisense oligonucleotides (ASOs) regulates a specific set of genes, including the key adipokines adiponectin and adipsin, and effectively improves hyperglycemia and insulin resistance in high-fat-fed mice without affecting body weight.
|
25316675 |
2014 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
GE treated groups improved the glucose tolerance, attenuated hyperglycemia and hyperinsulinemia in the mice by up-regulating the adiponectin and GLUT-4 gene expressions.
|
23259700 |
2012 |
|
Hyperglycemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Accumulated data suggest that both adiponectin levels and polymorphisms in the ADIPOQ gene are linked to the risk of CAD in patients with hyperglycemia, and that these associations seem to be independent from each other, even if adiponectin levels are partly dependent on ADIPOQ.
|
22147092 |
2011 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Improvements in hyperglycaemia and hypoadiponectinaemia following weight loss are associated with reduced skeletal muscle APPL1, and increased plasma adiponectin levels and muscle AMPK phosphorylation.
|
21562756 |
2011 |
|
Hyperglycemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The adiponectin SNP276 T variant and central obesity had independent and additive effects on hyperglycemia risks.
|
20466332 |
2010 |
|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
We determined the associations between esophagectomy-induced stress hyperglycemia (> or =30 mg/dl increases in blood glucose during surgery) and genetic polymorphisms for C-reactive protein (CRP), tumor necrosis factor (TNF)-alpha, -beta, interferon-gamma, transforming growth factor-beta1, interleukin (IL)-1beta, IL-2, IL-4, IL-6, IL-6 receptors, IL-10, IL-12beta, adiponectin, and peroxisome proliferator-activated receptor-gamma.
|
20145925 |
2010 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
We report that STZ-induced diabetic mice exhibited decreased Adipo levels and hyperglycemia which may be alleviated by hydrodynamic injection of the Adipo gene.
|
17868184 |
2007 |
|
Hyperglycemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The combined effects of PPARG Pro12Ala and APM1 G-11391A SNPs showed no interaction on the risk of 6-year hyperglycemia.
|
16567542 |
2006 |
|
Hyperglycemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Expression of AdipoR isoforms can be regulated by hyperinsulinaemia and hyperglycaemia with the consequence of increased sensitivity or resistance to specific forms of adiponectin.
|
17052201 |
2006 |
|
Hyperglycemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin levels at baseline were associated with the development of hyperglycemia (P = 0.005), but the predictive effects on the risk for hyperglycemia were independent of adiponectin genotypes.
|
15047634 |
2004 |