Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
The Protective Role of Adiponectin for Lipoproteins in End-Stage Renal Disease Patients: Relationship with Diabetes and Body Mass Index.
|
30911344 |
2019 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, higher adiponectin levels are associated with a higher risk of ESRD independent of conventional risk factors, BMI, and metabolic syndrome components.
|
31323071 |
2019 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
In both type 1 and type 2 diabetes (T2D) patients with DKD, elevated adiponectin serum levels have been observed, and adiponectin serum level is a prognostic factor of end-stage renal disease.
|
28402446 |
2017 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Pooled analysis of GENEDIAB and GENESIS studies showed that baseline plasma adiponectin levels were higher in subjects with established/advanced DN at inclusion (P < 0.0001) and in subjects who developed end-stage renal disease (ESRD) at follow-up (P < 0.0001).
|
28499019 |
2017 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
BEFREE |
The associations between elevated adiponectin and end-stage renal disease are well recognized and thought to be at least partially explained by reduced renal clearance.
|
27368123 |
2017 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Compared with controls, phosphorylation of the adiponectin downstream effector adenosine monophosphate-activated protein kinase (AMPK) was higher in ESRD while acetyl-CoA carboxylase phosphorylation (ACC-P) and carnitine palmitoyl transferase-1 (CPT-1) levels were lower.
|
25049200 |
2014 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
RGD |
Changes of adiponectin and its receptors in rats following chronic renal failure.
|
24028144 |
2014 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Thus, our study suggests that adipose tissue production of adiponectin contributes to the high plasma levels seen in end-stage renal disease.
|
23283133 |
2013 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
CTD_human |
Increased production of proinflammatory cytokines in adipose tissue of patients with end-stage renal disease.
|
19539174 |
2009 |
Kidney Failure, Chronic
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
Here we determined the predictive value of serum adiponectin levels and 8 adiponectin gene polymorphisms for mortality, cardiovascular events and end-stage renal disease in type I diabetic patients.
|
18496510 |
2008 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Serum adiponectin and progression of diabetic nephropathy in patients with type 1 diabetes.
|
18346990 |
2008 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These studies show that high serum adiponectin levels predict mortality and progression to end stage renal disease in type I diabetic patients.
|
18496510 |
2008 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
LHGDN |
Total and high molecular weight adiponectin concentrations in plasma of patients with end-stage renal disease before and after peritoneal dialysis.
|
18315699 |
2008 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
To investigate this paradox, we examined the distribution of adiponectin isoforms, the expression of adiponectin receptor (AdipoR) mRNA on peripheral blood mononuclear cells (PBMC) in 41 patients with ESKD on haemodialysis and 41 matched controls, and its function by adenosine monophosphate-activated protein kinase (AMPK) phosphorylation of AdipoR on PBMC.
|
17005524 |
2007 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Adiponectin levels were also higher in patients with ESKD compared with controls (P < .0005), and although levels were lower in the transplant group, they remained higher than in controls (P < .0001).
|
17697862 |
2007 |
Kidney Failure, Chronic
|
0.600 |
Biomarker
|
disease |
LHGDN |
Altered relationship between body fat and plasma adiponectin in end-stage renal disease.
|
15736110 |
2005 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Clinically, high plasma adiponectin level was associated with low cardiovascular event rate in patients with chronic renal failure.
|
15096450 |
2004 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
In a cohort of 204 (62% males) ESRD patients aged 52 +/- 1 years the following parameters were studied: presence of CVD, body composition, plasma adiponectin (N= 107), cholesterol, triglycerides, HDL-cholesterol, serum leptin, high-sensitivity C-reactive protein (hs-CRP), urinary albumin excretion (UAE), and single-nucleotide polymorphisms (SNPs) in the apM1 gene at positions -11391, -11377, 45, and 276.
|
14675060 |
2004 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Markedly (P < 0.0001) elevated median plasma adiponectin levels were observed in ESRD patients (22.2 microg/mL), especially type 1 diabetic patients (36.8 microg/mL), compared to control subjects (12.2 microg/mL).
|
14675060 |
2004 |
Kidney Failure, Chronic
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Although plasma levels of adiponectin, a recently discovered anti-inflammatory and antiatherogenic adipocytokine, are markedly elevated in ESRD, gene expression of adiponectin (ApM1) has not been analyzed in ESRD patients.
|
15200411 |
2004 |