|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
This review focuses on the pathophysiology of insulin and adenosine receptors and l-arginine and adenosine membranes transporters giving an overview of the key adipokines leptin and adiponectin in the foetoplacental vasculature in GDM.
|
30660686 |
2020 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The aim of the current clinical trial study was to explore the effects of ALA supplementation on maternal circulating values of adiponectin (A), leptin (L); and A/L, L/A, adiponectin/homeostatic model assessment for insulin resistance (A/H), and malondialdehyde/total antioxidant capacity (MDA/TAC) ratios in pregnant women with gestational diabetes mellitus (GDM).
|
30303695 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
In this sense, 1st-2nd trimester-released biomarkers found in maternal plasma including adipose tissue-derived factors such as adiponectin, visfatin, omentin-1, fatty acid-binding protein-4 and retinol binding-protein-4 have shown correlations with GDM development.
|
31666083 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Glucose, triglycerides, leptin, and lipocalin-2 were higher, while adiponectin was lower, in GDM (p < 0.05).
|
29898442 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
sCD163 and adiponectin were dysregulated in GDM, independent of body mass.
|
30548982 |
2019 |
|
Gestational Diabetes
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
The aim of this study was to investigate the correlations and interactions between the polymorphisms of insulin resistance-related genes (ADIPOQ rs2241766), inflammation factors (TNF-α rs1800629, IL-6 rs1800795), obesity-related genes (GNB3 rs5443, ADRB rs1042714), and risk factors for gestational diabetes mellitus (GDM) such as diet structure in the development of GDM.
|
29519182 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Plasma leptin and adiponectin concentrations were measured in 160 women at approximately 12 weeks following pregnancy with GDM and compared with infant weight for length z-score at 1 year of age after adjustment for maternal and infant demographic variables.
|
29172804 |
2019 |
|
Gestational Diabetes
|
0.600 |
PosttranslationalModification
|
phenotype |
BEFREE |
Secondly, maternal obesity (in the absence of gestational diabetes) was associated with (i) elevated DNA methylation of the leptin promoter on fetal side only, (ii) hypomethylation of the adiponectin promoter on the maternal side only, (iii) significantly low levels of leptin receptor protein (albeit in the absence of differences in mRNA levels and promoter DNA methylation), (iv) significantly low levels of adiponectin receptor 1 mRNA expression on the maternal side only, and (v) elevated DNA methylation of the adiponectin receptor 2 promoter on the maternal side only.
|
30732639 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Adiponectin may be a useful biomarker for predicting GDM in pregnant women.
|
30470912 |
2019 |
|
Gestational Diabetes
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Maternal GDM increased adipose mRNA levels of peroxisome proliferator-activated receptor gamma (Pparg) and adiponectin (Adipoq) in 31-week-old CD-fed male offspring, and increased mRNA levels of insulin receptor (Insr) and lipoprotein lipase (Lpl) in 31-week-old male offspring on both diets.
|
30698664 |
2019 |
|
Gestational Diabetes
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Insulin, HOMA-IR, and adiponectin levels mediated the WHR-GDM association by 9% to 11%; corresponding mediation proportions for the WC-GDM association were 35% to 41% (all P < 0.04).
|
30461219 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Elevated leptin and decreased adiponectin concentrations associated with adverse metabolic traits and were most likely driven by higher obesity prevalence among GDM offspring.
|
31639770 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Serum adiponectin was negatively correlated with maternal age and HOMA-IR in the NP group (p < 0.05 all) and with placental weight and serum omentin in the GDM group (p < 0.05 all).
|
31076892 |
2019 |
|
Gestational Diabetes
|
0.600 |
GeneticVariation
|
phenotype |
BEFREE |
To quantitatively evaluate the association between <i>ADIPOQ +45T/G</i>, <i>+276G/T</i>, and <i>-11377C/G</i> polymorphisms and the risk of GDM.
|
30863757 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
HMW adiponectin did not improve prediction of IADPSG GDM (AUC 0.84, sensitivity 64%, specificity 97.9%, P = 0.22) compared to FG and maternal factors (0.79, 56%, 93.8%).
|
29900538 |
2019 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Our findings suggest that omentin-1, rather than adiponectin, could be useful as a predictor of preterm birth in patients with gestational diabetes mellitus.
|
30320137 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Adiposity, low hip circumference, serum biomarkers (increased level of alanine aminotransferase, gamma-glutamyl transferase, uric acid and C-reactive protein, and decreased level of adiponectin and vitamin D), an unhealthy dietary pattern (increased consumption of processed meat and sugar-sweetened beverages, decreased intake of whole grains, coffee and heme iron, and low adherence to a healthy dietary pattern), low level of education and conscientiousness, decreased physical activity, high sedentary time and duration of television watching, low alcohol drinking, smoking, air pollution, and some medical conditions (high systolic blood pressure, late menarche age, gestational diabetes, metabolic syndrome, preterm birth) presented robust evidence for increased risk of T2DM.
|
29558518 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Our aim was to study the expression of adipokine-encoding genes (leptin, adiponectin, and angiopoietin-like protein 4 (ANGPTL4)) in human umbilical vein endothelial cells (HUVECs) and adipokine concentration in cord blood from women with gestational diabetes mellitus (GDM) depending on glycaemic targets.
|
29861725 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The expression of adipokines, leptin, and resistin were significantly increased, but adiponectin was decreased in OATs from patients with GDM compared with those without GDM.
|
30020508 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Serum adiponectin was lower in women with GDM and GIGT at both 1-year and 3-years (both P ≤ 0.002), whereas chemerin, RBP-4, CRP and PAI-1 showed no differences across the 4 groups.
|
30301460 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
The ratio of ficolin-3/adiponectin at 16-18 weeks of gestation was changed in pregnant women who subsequently developed GDM, and might provide effective early predicting and screening for GDM.
|
28445618 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Pearson's correlation analysis of adiponectin and resistin in all the subjects with various GDM risk factors showed a negative association of adiponectin (r = -0.32, p = .05) and a positive correlation of resistin (r = 0.41, p = .01) with LDL cholesterol.
|
29207892 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Among the four hormones, adiponectin was inversely associated with infant growth in both the GDM (β weight-for-height=-2·49; 95 % CI -3·83, -1·15; P<0·001; β head-circumference=-0·39; 95 % CI -0·65, -0·13; P=0·003) and healthy groups (β weight-for-height=-1·42; 95 % CI -2·38, -0·46; P=0·003; β head-circumference=-0·15; 95 % CI -0·27, -0·03; P=0·007).
|
30375294 |
2018 |
|
Gestational Diabetes
|
0.600 |
Biomarker
|
phenotype |
BEFREE |
Reduced adiponectin seems to be a pathogenic co-factor in GDM, even independent of BMI, affecting materno-fetal metabolism.
|
30355290 |
2018 |
|
Gestational Diabetes
|
0.600 |
AlteredExpression
|
phenotype |
BEFREE |
Adiponectin levels were reduced -although not significantly- in GDM- and NGT-obese women compared to their non-obese counterparts.
|
29337272 |
2018 |