|
Eosinophil count procedure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Carcinogenesis
|
0.020 |
AlteredExpression
|
phenotype |
BEFREE |
Moreover, upregulation of KIF3B was also observed in OSCC, which promoted tumorigenesis of OSCC.
|
30720171 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
KIF3B has also been implicated in carcinogenesis such as in hepatocellular carcinoma cells.
|
31157987 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
MiR-127-3p targeted KIF3B to inhibit the development of OSCC through suppressing cell proliferation, migration and invasion.
|
30720171 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We also found KIF3B was significantly associated to the pTNM stage (*<i>p</i> = 0.018), lymph node metastasis (*<i>p</i> = 0.040) and vascular invasion (*<i>p</i> = 0.034).
|
31157987 |
2019 |
|
Liver carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
KIF3B has also been implicated in carcinogenesis such as in hepatocellular carcinoma cells.
|
31157987 |
2019 |
|
Liver carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
KIF3B protein level was increased in HCC tissues compared with the adjacent non-tumorous tissues.
|
24368420 |
2014 |
|
Adenomatous Polyposis Coli
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, we show that KIF3B, a member of the kinesin superfamily proteins (KIFs), supports the transport of vesicles simultaneously containing NMDAR subunit 2A (NR2A) and the adenomatous polyposis coli (APC) complex.
|
31746486 |
2020 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, we propose that KIF3B transports NR2A/APC complex and that its dysfunction is responsible for SCZ pathogenesis.
|
31746486 |
2020 |
|
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
MiR-127-3p targets KIF3B to inhibit the development of oral squamous cell carcinoma.
|
30720171 |
2019 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
|
31773695 |
2019 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
The possible effects of KIF3B on tumor growth were assessed <i>in vivo</i>.
|
31157987 |
2019 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of KIF3B has not been studied in pancreatic cancer along with its clinical significance.
|
31157987 |
2019 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of KIF3B has not been studied in pancreatic cancer along with its clinical significance.
|
31157987 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
Biomarker
|
disease |
BEFREE |
We also found KIF3B was significantly associated to the pTNM stage (*<i>p</i> = 0.018), lymph node metastasis (*<i>p</i> = 0.040) and vascular invasion (*<i>p</i> = 0.034).
|
31157987 |
2019 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
LEF-AS1 participates in occurrence of colorectal cancer through adsorbing miR-505 and promoting KIF3B expression.
|
31773695 |
2019 |
|
Seminoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Using western-blotting and semi-quantitative PCR we found high protein levels of KIF3b enrichment in seminoma tissue despite the mRNA levels remaining equivalent to that of normal testicular tissues.
|
28161539 |
2017 |
|
Malignant Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We further leverage this integrative data to uncover expressed mutations in several known cancer genes as well as a recurrent mutation in the motor domain of KIF3B that significantly affects kinesin-microtubule interactions.
|
27723755 |
2016 |
|
Colonic Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We included 1721 patients with CD of which 524 (30.4%) were pCD+ and 1197 were pPCD. pCD was associated with distal colonic disease (Odds ratio 5.54 [3.23-9.52], P < 0.001), stricturing disease behavior (1.44 [1.14-1.81], P = 0.002) and family history of inflammatory bowel disease (4.98 [3.30-7.46], P < 0.001). pCD was associated with higher anti-sacharomyces cerevisae antibodies IgA (P < 0.001) and OmpC (P = 0.008) antibody levels. pCD was associated with known inflammatory bowel disease loci, including KIF3B, CRTC3, TRAF3IP2, JAZF1, NRIP1, MST1, FUT2, and PTGER (all P < 0.05).
|
26937622 |
2016 |
|
Inflammatory Bowel Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We included 1721 patients with CD of which 524 (30.4%) were pCD+ and 1197 were pPCD. pCD was associated with distal colonic disease (Odds ratio 5.54 [3.23-9.52], P < 0.001), stricturing disease behavior (1.44 [1.14-1.81], P = 0.002) and family history of inflammatory bowel disease (4.98 [3.30-7.46], P < 0.001). pCD was associated with higher anti-sacharomyces cerevisae antibodies IgA (P < 0.001) and OmpC (P = 0.008) antibody levels. pCD was associated with known inflammatory bowel disease loci, including KIF3B, CRTC3, TRAF3IP2, JAZF1, NRIP1, MST1, FUT2, and PTGER (all P < 0.05).
|
26937622 |
2016 |
|
Perianal Crohn's disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We included 1721 patients with CD of which 524 (30.4%) were pCD+ and 1197 were pPCD. pCD was associated with distal colonic disease (Odds ratio 5.54 [3.23-9.52], P < 0.001), stricturing disease behavior (1.44 [1.14-1.81], P = 0.002) and family history of inflammatory bowel disease (4.98 [3.30-7.46], P < 0.001). pCD was associated with higher anti-sacharomyces cerevisae antibodies IgA (P < 0.001) and OmpC (P = 0.008) antibody levels. pCD was associated with known inflammatory bowel disease loci, including KIF3B, CRTC3, TRAF3IP2, JAZF1, NRIP1, MST1, FUT2, and PTGER (all P < 0.05).
|
26937622 |
2016 |
|
Primary malignant neoplasm
|
0.010 |
GeneticVariation
|
group |
BEFREE |
We further leverage this integrative data to uncover expressed mutations in several known cancer genes as well as a recurrent mutation in the motor domain of KIF3B that significantly affects kinesin-microtubule interactions.
|
27723755 |
2016 |