SLC22A8, solute carrier family 22 member 8, 9376

N. diseases: 37; N. variants: 1
Disease: Hyperuricemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0740394
Disease: Hyperuricemia
Hyperuricemia 		0.020 Biomarker disease BEFREE Therefore, we propose a molecular mechanism for the induction of hyperuricemia by diuretics: the diuretics enter proximal tubular cells via basolateral OAT1 and/or OAT3 and may then interfere with the NPT4-mediated apical urate efflux in the renal proximal tubule. 27614971 2017
CUI: C0740394
Disease: Hyperuricemia
Hyperuricemia 		0.020 Biomarker disease BEFREE These results indicate that UR-1102 achieves strong uricosuric effects by selectively inhibiting URAT1 over OAT1 and OAT3 in monkeys, and could be a novel therapeutic option for patients with gout or hyperuricemia. 26907620 2016