NRXN1, neurexin 1, 9378

N. diseases: 139; N. variants: 41
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease LHGDN Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. 17989066 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Comparative genome hybridization suggests a role for NRXN1 and APBA2 in schizophrenia. 17989066 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Among the genes disrupted by the remaining rare CNVs are MYT1L, CTNND2, NRXN1, and ASTN2, genes that play an important role in neuronal functioning but--except for NRXN1--have not been associated with schizophrenia before. 18940311 2008
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE We conclude that NRXN1 deletions affecting exons confer risk of schizophrenia. 18945720 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Over the last 12 months, a series of major articles have reported associations with schizophrenia of copy number variants at 1q21, 15q11.2, 15q13.3, 16p11.2, 22q12, and Neurexin 1 loci. 18990708 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE There is evidence both for an increased burden of CNVs in schizophrenia and that risk is conferred by specific large deletions at 1q21.1 and at 15q13.2 and by deletions of NRXN1 which encodes the synaptic scaffolding protein neurexin 1. 19345090 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE We have genotyped 15 single nucleotide polymorphisms (SNPs) spanning the NRXN1 and NRXN3 genes in 195 unrelated patients with schizophrenia for whom information about their smoking status and number of cigarettes smoked per day (CPD) was obtained. 19658047 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease MGD Mouse neurexin-1alpha deletion causes correlated electrophysiological and behavioral changes consistent with cognitive impairments. 19822762 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE We provide support for three previous findings in schizophrenia, as we identified one deletion in a case at 1q21.1, one deletion within NRXN1, and four duplications in cases and one in a control subject at 16p13.1, a locus first implicated in autism and later in schizophrenia. 19880096 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Heterozygous copy-number variants and SNPs of CNTNAP2 and NRXN1, two distantly related members of the neurexin superfamily, have been repeatedly associated with a wide spectrum of neuropsychiatric disorders, such as developmental language disorders, autism spectrum disorders, epilepsy, and schizophrenia. 19896112 2009
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease CTD_human At a gene level, CAM genes associated in all three samples (NRXN1 and CNTNAP2), which were previously implicated in specific language disorder, autism and schizophrenia. 20157312 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 AlteredExpression disease BEFREE NRXN1 is highly expressed in brain and has been shown recently to be associated with ASD, schizophrenia, cognitive and behavioral abnormalities, and alcohol and nicotine dependence. 20162629 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Rare NRXN1 promoter variants in patients with schizophrenia. 20347009 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Interestingly, NRXN1 deletions have been reported in schizophrenia, whereas CNTNAP2 variants are associated with several neuropsychiatric phenotypes. 20421335 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Large NRXN1 deletions have also been associated with schizophrenia. 20860064 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE These include ZNF804A, TCF4 and NRGN, which contain common variants that weakly increase schizophrenia susceptibility, and NRXN1, in which rare copy number variants have a greater impact on schizophrenia risk. 20934321 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE We found five patients with a CNV occurring in one of the regions most convincingly implicated as risk factors for schizophrenia: NRXN1 and the 16p13.1 regions were found to be deleted in single patients and 15q11.2 in 2 patients, whereas the 15q13.3 region was duplicated in one patient. 20967226 2010
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE We review the evidence for the role of neurexin-1α in schizophrenia and ASD, and consider how genetic disruption of neurexin-1α may underpin the neuropathology contributing to these distinct neurodevelopmental disorders. 21262241 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE The data strongly confirm the association of schizophrenia with 1q21.1, 15q13.3, and 22q11.21 deletions, 16p11.2 duplications, and exonic NRXN1 deletions. 21285140 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease CTD_human The data strongly confirm the association of schizophrenia with 1q21.1, 15q13.3, and 22q11.21 deletions, 16p11.2 duplications, and exonic NRXN1 deletions. 21285140 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE Overall, however, the results do not suggest the existence of rare, highly penetrant NRXN1 mutations in patients with schizophrenia. 21288692 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease CTD_human Our findings link NRXN2 disruption to the pathogenesis of ASD for the first time and further strengthen the involvement of NRXN1 in SCZ, supporting the notion of a common genetic mechanism in these disorders. 21424692 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 Biomarker disease BEFREE Our findings link NRXN2 disruption to the pathogenesis of ASD for the first time and further strengthen the involvement of NRXN1 in SCZ, supporting the notion of a common genetic mechanism in these disorders. 21424692 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE However, we did not find any association with age-at-onset of schizophrenia with NRXN1 polymorphisms. 21477380 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia
0.700 GeneticVariation disease BEFREE However, the manner in which NRXN1 gene variation may be related to brain morphology to confer risk for ASD or schizophrenia is unknown. 21687627 2011