Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Unlike LPL and HL, EL is located in the vascular endothelial cells and its expression is highly regulated by cytokines and physical forces, suggesting that it may play a role in the development of atherosclerosis.
|
12401876 |
2002 |
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Unlike LPL and HL, EL is located in the vascular endothelial cells and its expression is highly regulated by cytokines and physical forces, suggesting that it may play a role in the development of atherosclerosis.
|
12401876 |
2002 |
Hemolytic-Uremic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The distribution of EDL 933 O island 122 (OI-122) was investigated in 70 strains of Verocytotoxin-producing Escherichia coli (VTEC) of multiple serotypes that were classified into five "seropathotypes" (A through E) based on the reported occurrence of serotypes in human disease, in outbreaks, and/or in the hemolytic-uremic syndrome (HUS).
|
14605120 |
2003 |
Hypertensive disease
|
0.210 |
Biomarker
|
group |
RGD |
Increased expression of endothelial lipase in rat models of hypertension.
|
15914124 |
2005 |
Hypertensive disease
|
0.210 |
AlteredExpression
|
group |
BEFREE |
Increased expression of endothelial lipase in rat models of hypertension.
|
15914124 |
2005 |
Vascular Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Thus, EL might have a role in the local pathophysiology of vascular diseases.
|
15914124 |
2005 |
Cardiovascular Diseases
|
0.060 |
GeneticVariation
|
group |
LHGDN |
Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans.
|
16023652 |
2006 |
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans.
|
16354105 |
2006 |
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans.
|
16354105 |
2006 |
Metabolic Syndrome X
|
0.060 |
Biomarker
|
disease |
BEFREE |
We report, to our knowledge for the first time, that human plasma EL concentrations, in both post-heparin and routine pre-heparin plasma, are significantly associated with metabolic syndrome features and with subclinical atherosclerosis.
|
16354105 |
2006 |
Cardiovascular Diseases
|
0.060 |
Biomarker
|
group |
BEFREE |
Endothelial lipase: its role in cardiovascular disease.
|
16498510 |
2006 |
Metabolic Syndrome X
|
0.060 |
Biomarker
|
disease |
BEFREE |
Taken together, data suggest that EL is one of several key regulatory enzymes of lipoprotein-lipid metabolism and that a proinflammatory state, such as the metabolic syndrome, may be implicated in the processes relating plasma EL concentrations and lipoprotein concentrations.
|
16498510 |
2006 |
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
EL is the predominant TLG family member in the human placenta present at both interfaces.EL and LPL are dysregulated in IUGR.
|
17356047 |
2007 |
Myocardial Infarction
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels.
|
17526978 |
2007 |
Acute myocardial infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI.
|
17526978 |
2007 |
Dyslipidemias
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The contribution to dyslipidemia of 20 selected single nucleotide polymorphisms of 13 genes reported in the literature to be associated with plasma lipid levels (ABCA1, ADRB2, APOA5, APOC3, APOE, CETP, LIPC, LIPG, LPL, MDR1, MTP, SCARB1, and TNF) was assessed by longitudinally modeling more than 4400 plasma lipid determinations in 438 antiretroviral therapy-treated participants during a median period of 4.8 years.
|
17700364 |
2007 |
Coronary Arteriosclerosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population.
|
17986713 |
2008 |
Coronary heart disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population.
|
17986713 |
2008 |
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.
|
17986713 |
2008 |
Coronary Artery Disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.
|
17986713 |
2008 |
Acute myocardial infarction
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels.
|
17986713 |
2008 |
Coronary heart disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We determined the relationship between inflammatory markers and EL levels in a cohort of healthy persons recruited on the basis of family history of coronary disease.
|
18212282 |
2008 |
Coronary Artery Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We determined the relationship between inflammatory markers and EL levels in a cohort of healthy persons recruited on the basis of family history of coronary disease.
|
18212282 |
2008 |
Metabolic Syndrome X
|
0.060 |
Biomarker
|
disease |
BEFREE |
Endothelial lipase (EL) is a plasma lipase that we previously reported to be significantly correlated with all features of the metabolic syndrome in humans, including directly with measures of adiposity and inversely with high-density lipoprotein cholesterol levels.
|
18212282 |
2008 |
Obesity
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We hypothesized that inflammation associated with obesity results in upregulation of EL.
|
18212282 |
2008 |