LIPG, lipase G, endothelial type, 9388

N. diseases: 62; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 AlteredExpression disease BEFREE Unlike LPL and HL, EL is located in the vascular endothelial cells and its expression is highly regulated by cytokines and physical forces, suggesting that it may play a role in the development of atherosclerosis. 12401876 2002
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 AlteredExpression disease BEFREE Unlike LPL and HL, EL is located in the vascular endothelial cells and its expression is highly regulated by cytokines and physical forces, suggesting that it may play a role in the development of atherosclerosis. 12401876 2002
CUI: C0019061
Disease: Hemolytic-Uremic Syndrome
Hemolytic-Uremic Syndrome 		0.010 GeneticVariation disease BEFREE The distribution of EDL 933 O island 122 (OI-122) was investigated in 70 strains of Verocytotoxin-producing Escherichia coli (VTEC) of multiple serotypes that were classified into five "seropathotypes" (A through E) based on the reported occurrence of serotypes in human disease, in outbreaks, and/or in the hemolytic-uremic syndrome (HUS). 14605120 2003
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.210 Biomarker group RGD Increased expression of endothelial lipase in rat models of hypertension. 15914124 2005
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.210 AlteredExpression group BEFREE Increased expression of endothelial lipase in rat models of hypertension. 15914124 2005
CUI: C0042373
Disease: Vascular Diseases
Vascular Diseases 		0.020 Biomarker group BEFREE Thus, EL might have a role in the local pathophysiology of vascular diseases. 15914124 2005
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.100 Biomarker disease BEFREE We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans. 16354105 2006
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.100 Biomarker disease BEFREE We hypothesized that EL concentrations would be associated with decreased HDL-C and increased atherosclerosis in humans. 16354105 2006
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.060 Biomarker group BEFREE Endothelial lipase: its role in cardiovascular disease. 16498510 2006
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.060 GeneticVariation group LHGDN Association of endothelial lipase gene (LIPG) haplotypes with high-density lipoprotein cholesterol subfractions and apolipoprotein AI plasma levels in Japanese Americans. 16023652 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.060 Biomarker disease BEFREE Taken together, data suggest that EL is one of several key regulatory enzymes of lipoprotein-lipid metabolism and that a proinflammatory state, such as the metabolic syndrome, may be implicated in the processes relating plasma EL concentrations and lipoprotein concentrations. 16498510 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.060 Biomarker disease BEFREE We report, to our knowledge for the first time, that human plasma EL concentrations, in both post-heparin and routine pre-heparin plasma, are significantly associated with metabolic syndrome features and with subclinical atherosclerosis. 16354105 2006
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.020 GeneticVariation disease LHGDN Endothelial lipase gene polymorphism is associated with acute myocardial infarction, independently of high-density lipoprotein-cholesterol levels. 17526978 2007
CUI: C0155626
Disease: Acute myocardial infarction
Acute myocardial infarction 		0.020 GeneticVariation disease BEFREE The 584C/T polymorphism of the EL gene was associated with AMI independently of HDL-C levels and thus may be involved in the pathogenesis of AMI. 17526978 2007
CUI: C0015934
Disease: Fetal Growth Retardation
Fetal Growth Retardation 		0.010 Biomarker phenotype BEFREE EL is the predominant TLG family member in the human placenta present at both interfaces.EL and LPL are dysregulated in IUGR. 17356047 2007
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.010 GeneticVariation group BEFREE The contribution to dyslipidemia of 20 selected single nucleotide polymorphisms of 13 genes reported in the literature to be associated with plasma lipid levels (ABCA1, ADRB2, APOA5, APOC3, APOE, CETP, LIPC, LIPG, LPL, MDR1, MTP, SCARB1, and TNF) was assessed by longitudinally modeling more than 4400 plasma lipid determinations in 438 antiretroviral therapy-treated participants during a median period of 4.8 years. 17700364 2007
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.100 GeneticVariation disease BEFREE Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population. 17986713 2008
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 AlteredExpression disease BEFREE We determined the relationship between inflammatory markers and EL levels in a cohort of healthy persons recruited on the basis of family history of coronary disease. 18212282 2008
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.100 GeneticVariation disease BEFREE Protective effect of an endothelial lipase gene variant on coronary artery disease in a Chinese population. 17986713 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 GeneticVariation disease LHGDN In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels. 17986713 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 AlteredExpression disease BEFREE We determined the relationship between inflammatory markers and EL levels in a cohort of healthy persons recruited on the basis of family history of coronary disease. 18212282 2008
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.100 GeneticVariation disease BEFREE In conclusion, our observation that the EL 584T allele was associated with protection from CAD in this Chinese population replicates the findings in a Japanese study, which found a similar association of this allele with acute myocardial infarction, independent of HDL-C levels. 17986713 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.060 Biomarker disease BEFREE Endothelial lipase (EL) is a plasma lipase that we previously reported to be significantly correlated with all features of the metabolic syndrome in humans, including directly with measures of adiposity and inversely with high-density lipoprotein cholesterol levels. 18212282 2008
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.050 Biomarker disease BEFREE Since type 2 diabetes is associated with chronic subclinical inflammation, we have determined whether serum EL concentration is increased in type 2 diabetes and investigated the effect of insulin on EL. 18433755 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.020 AlteredExpression disease BEFREE We hypothesized that inflammation associated with obesity results in upregulation of EL. 18212282 2008