LIPG, lipase G, endothelial type, 9388

N. diseases: 62; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011265
Disease: Presenile dementia
Presenile dementia 		0.010 AlteredExpression disease BEFREE An analysis by classification of dementia severity according to clinical dementia rating (CDR) showed that the EL levels were significantly higher in the CDR1 group (mild dementia), as compared to CDR0 (no dementia), CDR0.5 (very mild), and CDR2 (moderate) groups. 31216999 2019
CUI: C0015672
Disease: Fatigue
Fatigue 		0.010 Biomarker phenotype BEFREE At 20 weeks, soleus, EDL or diaphragm muscle was isolated (n = 8 in each case) and isometric force, work loop power output and fatigue resistance were measured. 30357516 2019
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.010 GeneticVariation disease BEFREE Findings from the present study reflect the association of EL and cognition, suggesting that the individuals with elevated plasma EL concentration are at an increased risk of cognitive impairment. 31216999 2019
CUI: C0497327
Disease: Dementia
Dementia 		0.010 AlteredExpression disease BEFREE An analysis by classification of dementia severity according to clinical dementia rating (CDR) showed that the EL levels were significantly higher in the CDR1 group (mild dementia), as compared to CDR0 (no dementia), CDR0.5 (very mild), and CDR2 (moderate) groups. 31216999 2019
CUI: C0002895
Disease: Anemia, Sickle Cell
Anemia, Sickle Cell 		0.010 Biomarker disease BEFREE Here, we examined effects of nitrite on muscle strength, exercise capacity, and on contractile properties of fast-(extensor digitorum longus, EDL) and slow-twitch (soleus) muscles in SCD mice. 30114530 2018
CUI: C0013264
Disease: Muscular Dystrophy, Duchenne
Muscular Dystrophy, Duchenne 		0.010 Biomarker disease BEFREE In addition, isolated ex vivo contractile properties and repeated eccentric contractions showed that mdx/utrn+/- does not significantly worsen the function of dystrophic EDL muscles, which are mainly composed of fast-twitch fibers that are preferentially affected in DMD. 29879154 2018
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.010 Biomarker disease BEFREE Therefore, GAP-EDL makes it possible to image ER-enriched endometriosis and cancer. 30356372 2018
CUI: C3539878
Disease: Triple Negative Breast Neoplasms
Triple Negative Breast Neoplasms 		0.010 Biomarker disease BEFREE LIPG possesses a lipase-dependent function that supports cancer cell proliferation and a lipase-independent function that promotes invasiveness, stemness and basal/epithelial-mesenchymal transition features of TNBC. 29350614 2018
CUI: C4722518
Disease: Triple-Negative Breast Carcinoma
Triple-Negative Breast Carcinoma 		0.010 Biomarker disease BEFREE LIPG possesses a lipase-dependent function that supports cancer cell proliferation and a lipase-independent function that promotes invasiveness, stemness and basal/epithelial-mesenchymal transition features of TNBC. 29350614 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 GeneticVariation group BEFREE We identified two risk alleles that were significant cis-eQTLs for FADS2 (rs1535) and COLCA1 and 2 (rs3802842) genes in the normal transverse colon tissue and two risk alleles that were significant cis-eQTLs for the CABLES2 (rs2427308) and LIPG (rs7229639) genes in the normal sigmoid colon tissue, but not tumor tissue. 28506205 2017
CUI: C0086132
Disease: Depressive Symptoms
Depressive Symptoms 		0.010 GeneticVariation phenotype BEFREE Together, these findings implicate the Asn396Ser variant of LIPG in the pathogenesis of depressive symptoms in the general population. 27431295 2017
CUI: C0264714
Disease: Acute heart failure
Acute heart failure 		0.010 Biomarker disease BEFREE The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF. 28446761 2017
CUI: C0020445
Disease: Hypercholesterolemia, Familial
Hypercholesterolemia, Familial 		0.010 GeneticVariation disease BEFREE Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy. 27039080 2016
CUI: C0745103
Disease: Hyperlipoproteinemia Type IIa
Hyperlipoproteinemia Type IIa 		0.010 GeneticVariation disease BEFREE Changes in lipoprotein lipase and endothelial lipase mass in familial hypercholesterolemia during three-drug lipid-lowering combination therapy. 27039080 2016
CUI: C0339467
Disease: Proliferative retinopathy
Proliferative retinopathy 		0.010 GeneticVariation disease BEFREE Association of endothelial lipase Thr111Ile polymorphism with proliferative retinopathy in type 2 diabetes patients. 24852509 2014
CUI: C0155733
Disease: Atherosclerosis of aorta
Atherosclerosis of aorta 		0.010 AlteredExpression phenotype BEFREE Furthermore, we demonstrated that rEL mRNA was expressed by both endothelial cells and macrophages in the lesions of aortic atherosclerosis of WHHL rabbits. 22240910 2012
CUI: C0342883
Disease: Cholesteryl Ester Transfer Protein Deficiency
Cholesteryl Ester Transfer Protein Deficiency 		0.010 Biomarker disease BEFREE Resequencing CETP, LIPC and LIPG genes in Thai subjects with hyperalphalipoproteinemia. 22464213 2012
CUI: C0015414
Disease: Eye Neoplasms
Eye Neoplasms 		0.010 Biomarker group BEFREE Therapies that inhibit mitochondrial function and induce apoptosis within tumor cells, such as EDL-155 and curcumin, may offer novel therapeutic agents for ocular neoplasms such as retinoblastoma and uveal melanoma. 21730846 2011
CUI: C0035335
Disease: Retinoblastoma
Retinoblastoma 		0.010 Biomarker disease BEFREE Therapies that inhibit mitochondrial function and induce apoptosis within tumor cells, such as EDL-155 and curcumin, may offer novel therapeutic agents for ocular neoplasms such as retinoblastoma and uveal melanoma. 21730846 2011
CUI: C0220633
Disease: Uveal melanoma
Uveal melanoma 		0.010 Biomarker disease BEFREE Therapies that inhibit mitochondrial function and induce apoptosis within tumor cells, such as EDL-155 and curcumin, may offer novel therapeutic agents for ocular neoplasms such as retinoblastoma and uveal melanoma. 21730846 2011
CUI: C0149871
Disease: Deep Vein Thrombosis
Deep Vein Thrombosis 		0.010 GeneticVariation disease BEFREE Our data support a modest association between the LIPG rs2000813 variant and parameters of HDL metabolism, but no association between common genetic variants in LIPG and CAD or DVT risk. 20466371 2010
CUI: C0151950
Disease: Deep thrombophlebitis
Deep thrombophlebitis 		0.010 GeneticVariation disease BEFREE Lack of association between common genetic variation in endothelial lipase (LIPG) and the risk for CAD and DVT. 20466371 2010
CUI: C0205851
Disease: Germ cell tumor
Germ cell tumor 		0.010 Biomarker disease BEFREE Lipoprotein lipase and endothelial lipase in human testis and in germ cell neoplasms. 19780863 2010
CUI: C1963943
Disease: Atherothrombosis
Atherothrombosis 		0.010 GeneticVariation disease BEFREE Common variants in the endothelial lipase gene (LIPG) have been reported to be associated with HDL-C levels and atherothrombosis, but these findings were not consistent. 20466371 2010
CUI: C0155877
Disease: Allergic asthma
Allergic asthma 		0.010 Biomarker disease BEFREE Thus EL is a novel modulator of the progression of allergic asthma. 19168574 2009