LIPG, lipase G, endothelial type, 9388

N. diseases: 62; N. variants: 18
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.060 Biomarker disease BEFREE Thus far, the extensive investigations of LIPG have focused on its mechanisms and involvement in metabolic syndromes such as atherosclerosis. 28540715 2018
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.060 Biomarker disease BEFREE The association of EL with atherogenic lipid profile is altered in AHF and additionally modified by MetS, which strongly modulates EL- and lipid/lipoprotein-plasma levels in AHF. 28446761 2017
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.060 GeneticVariation disease BEFREE We examined associations between variants LIPG T111I (rs2000813) and LIPG i24582 (rs6507931), HDL and television viewing/computer use ("screen time") as a marker for physical inactivity in a population with high prevalence of metabolic syndrome. 19380136 2009
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.060 Biomarker disease BEFREE Endothelial lipase (EL) is a plasma lipase that we previously reported to be significantly correlated with all features of the metabolic syndrome in humans, including directly with measures of adiposity and inversely with high-density lipoprotein cholesterol levels. 18212282 2008
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.060 Biomarker disease BEFREE Taken together, data suggest that EL is one of several key regulatory enzymes of lipoprotein-lipid metabolism and that a proinflammatory state, such as the metabolic syndrome, may be implicated in the processes relating plasma EL concentrations and lipoprotein concentrations. 16498510 2006
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X
0.060 Biomarker disease BEFREE We report, to our knowledge for the first time, that human plasma EL concentrations, in both post-heparin and routine pre-heparin plasma, are significantly associated with metabolic syndrome features and with subclinical atherosclerosis. 16354105 2006