|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Blocking CD28/B7 interactions may be useful in preventing unwanted activation in allergy and autoimmune diseases, whereas enhancing this interaction can promote tumour rejection.
|
9416000 |
1998 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Like the HLA, the CD28/CTLA4 genes appear to be associated with genetic susceptibility to various autoimmune diseases.
|
10372542 |
1999 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
To determine whether antilymphocyte Abs to T cell costimulatory molecules are generated in patients with autoimmune diseases and, if they exist, to clarify the mechanism of their production and pathological roles, we investigated the presence of autoantibodies to CTLA-4 (CD152), CD28, B7-1 (CD80), and B7-2 (CD86) in serum samples obtained from patients with various autoimmune diseases and from normal subjects using recombinant fusion proteins.
|
10201965 |
1999 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Gene region 2q33 carrying genes for both CTLA4 and CD28 has been shown to be linked to many autoimmune diseases.
|
11509583 |
2001 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Cytotoxic T lymphocyte associated antigen 4 (CTLA-4), a structural homologue of CD28, has been reported to be an important negative regulator of autoimmune diseases.
|
11678454 |
2001 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Enhancement of T cell metabolism by Akt and more rapid CD28-independent T cell growth may contribute to the accumulation of excess immune cells and the development of lymphoma and autoimmunity.
|
12884297 |
2003 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
Absence of CTLA-4 expression in CD40L-/- mice suggests that signaling via both CD28 and CD40L is important for T cell activation and subsequent autoimmunity in mHgIA.
|
15494542 |
2004 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These results suggest that soluble CD28 could play an important role in the regulation of autoimmune diseases.
|
15086406 |
2004 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
SNPs in the 2q33 region within the genes of CD28 (+17T/C; intron 3) and CTLA4 (-318C/T; promoter and +49A/G; exon 1) are likely to affect T-cell proliferation and antigen presentation signaling, which may lead to altered sensitivity of allograft or self-tissue recognition and affect the incidence of autoimmune diseases.
|
16305681 |
2005 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These data support the hypothesis that CD28-B7 interactions play a critical role in the etiology of lethal autoimmune disease in scurfy mice by stimulating the differentiation of antigen-activated naive T cells into effector T cells.
|
17463170 |
2007 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
CTD_human |
In this study we have examined the effect of single-gene deletions for interferon (IFN)-gamma, interleukin (IL)-4, IL-6 or CD28 in B10.S (H-2(s)) mice on heavy metal-induced autoimmunity.
|
19077085 |
2009 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The data showed 4E5 function and suggested that blockade of CD80/CD28 co-stimulatory signal pathway with 4E5 is a promising strategy to decelerate the progression of lupus-like disease and other autoimmune diseases.
|
21978690 |
2011 |
|
Autoimmune Diseases
|
0.400 |
AlteredExpression
|
group |
BEFREE |
CD28 is one of the main activator receptors involved in systemic lupus erythematosus (SLE) pathogenesis, and its expression and serum levels are significantly higher in patients with SLE and other autoimmune diseases than in healthy controls (HC).
|
20390280 |
2011 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
These findings identify CD28 and CD80/CD86 as important molecular components of the interaction between myeloma cells and the bone marrow microenvironment, point to similar interaction for normal plasma cells, and suggest novel therapeutic strategies to target malignant and pathogenic (e.g., in allergy and autoimmunity) plasma cells.
|
21715687 |
2011 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) and CD28 have been reported to be important candidate genes for conferring susceptibility to autoimmunity.
|
22700162 |
2012 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
CD4(+)CD28(-) T cells arise through repeated antigenic stimulation and are present in diseased tissues of patients with various autoimmune disorders, including multiple sclerosis (MS).
|
25617471 |
2015 |
|
Autoimmune Diseases
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To replicate a single nucleotide polymorphism (SNP) of known genes for lupus (IRF5 rs10488631, PTPN22 rs2476601, BLK rs2736340 and TNFAIP3 rs5029939) and other autoimmune diseases (CD28 rs1980422, IL2RA rs2104286 and KIF5A rs1678542) on a newly studied Egyptian cohort to investigate the genetic disparity with different studied ethnic groups in relation to lupus susceptibility.
|
26092158 |
2015 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Self-Recognition Sensitizes Mouse and Human Regulatory T Cells to Low-Dose CD28 Superagonist Stimulation.
|
29441059 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
T cells are central to the detrimental alloresponses that develop in autoimmunity and transplantation, with CD28 costimulatory signals being key to T cell activation and proliferation.
|
28978798 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Moreover, after specific restimulation, PV1 blockade selectively blocked IFN-γ production by CD4+ lymphocytes Taken together, our data suggest that mPEG PV1-Fab' acts mainly on IFN-γ-producing CD4+ T cells and emphasize that this specific CD28 blockade strategy is a potential specific and alternative tool for the treatment of autoimmune disorders in the eye.
|
28248972 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
CD28/T-cell receptor (TCR)/cytotoxic T-lymphocyte antigen 4 (CTLA4) complex controls T-cell tolerance and autoimmunity in Hashimoto's thyroiditis (HT).
|
28660994 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
The detailed insight into these interactions reported here may inform the development of compounds that specifically inhibit the association of CD28 with these adaptor proteins to suppress excessive T cell responses, such as in allergies and autoimmune diseases.
|
27927989 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
CD28/CTLA4 and their ligands CD80 or CD86 costimulatory pathway play a pivotal role in autoimmune disease and organ transplantation.
|
28747139 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Thus, autoimmunity occurring in mice with CD28-deficient Tregs appears to be driven primarily by loss of T<sub>FR</sub> cell differentiation and function with resulting B cell-driven inflammation.
|
29093061 |
2017 |
|
Autoimmune Diseases
|
0.400 |
Biomarker
|
group |
BEFREE |
Challenges and opportunities in targeting the CD28/CTLA-4 pathway in transplantation and autoimmunity.
|
28525959 |
2017 |