CD28, CD28 molecule, 940

N. diseases: 364; N. variants: 11
Disease: Lymphopenia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.220 Biomarker disease RGD We have tested the therapeutic potential of a novel class of superagonistic CD28-specific antibodies that induce polyclonal T-cell proliferation without T-cell receptor engagement in an experimental rat model of T lymphopenia. 12750179 2003
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.220 Biomarker disease LHGDN Endotoxin-induced lymphopenia was constituted mainly by cells with an immature phenotype (CD45RA(+) CD45RO(-)) that were less likely to undergo apoptosis (CD28(+)), whereas cells with the highest rates of disappearance were characterized by an activated phenotype (CD45RA(-) CD45RO(+)) as well as a phenotype linked to apoptosis (CD95(+) CD28(-)). 11986289 2002
CUI: C0024312
Disease: Lymphopenia
Lymphopenia 		0.220 AlteredExpression disease BEFREE We report here an infant with clinical and laboratory features of SCID and selective CD4 lymphopenia and lack of CD28 expression on CD8(+) T cells. 9664084 1998