Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Abatacept is a biologic agent selectively targeting the T-cell costimulatory signal delivered through the CD80/86-CD28 pathway and was approved in December 2005 by the US Food and Drug Administration and in May 2007 by European Medicines Agency for the treatment of patients with rheumatoid arthritis in combination with methotrexate.
|
29922065 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Indeed, pharmacological blockade of CD28 costimulation using CTLA-4Ig (abatacept), approved for amelioration of RA, renders T cells dormant (anergic).
|
29500936 |
2018 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the present study, we co-cultured RA-FLS with or without anti-CD3/CD28-stimulated PBMC.
|
28833034 |
2017 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
CD28 and PTPN22 are associated with susceptibility to rheumatoid arthritis in Egyptians.
|
27125674 |
2016 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
A Combination of CD28 (rs1980422) and IRF5 (rs10488631) Polymorphisms Is Associated with Seropositivity in Rheumatoid Arthritis: A Case Control Study.
|
27092776 |
2016 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Natural Killer cells and CD28 null T-cells are suspected as role players in RA pathogenesis.
|
26658904 |
2015 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The expansion of CD4(+)CD28(null) cells in RA patients was associated with TNFA genotype, even at diagnosis, and linked to markers of aggressive disease in patient carriers of the minor allele.
|
25510954 |
2015 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Killer cell immunoglobulin-like receptors (KIR) expressed on surface of natural killer cells and CD28 null T-cells which are present in synovial membrane of RA.
|
24912006 |
2014 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Forty-four patients with RA, displaying a distinct CD4(+) CD28(null) T cell population in blood, were recruited for this study; the methylation status of the IFNG locus was examined in isolated T cell subsets, and intracellular cytokine production (IFN-γ, TNF, IL-17) and chemokine receptor expression (CXCR3, CCR6 and CCR7) were assessed by flow cytometry on T cells from the two compartments.
|
24313359 |
2014 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, The percentage of peripheral CD4+DR3+T cells of RA was significantly higher than that of healthy controls (HC), and this increased percentage of CD4+DR3+T cells was obviously up-regulated when stimulated with anti-CD3 and anti-CD28 antibody in RA patients.
|
24832108 |
2014 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cytokine-producing CD4+ T cells included the CD45RO+ and CD45RO- and the CD28+ and CD28- subsets in RA patients.
|
22594821 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The Ca(2+) influx was lower in anti-CD3 + anti-CD28-activated MNC from RA patients than healthy volunteers and suppressed by nifedipine.
|
22385242 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
PBMCs of healthy donors and RA patients were stimulated with CD3 and CD28 monoclonal antibodies to produce high levels of IL-17.
|
21691744 |
2012 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
High-density genetic mapping identifies new susceptibility loci for rheumatoid arthritis.
|
23143596 |
2012 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The CD28 gene is similarly down-regulated in CD4(+) lymphocytes from both healthy elderly people and patients with rheumatoid arthritis (RA) because of impaired protein-binding activity of the 'α' sequence in its promoter region.
|
20738421 |
2011 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The gene includes the CD28 IVS3 +17T/C polymorphism that could be associated with susceptibility to RA whereas the soluble concentrations of CD28 (sCD28) could be related to clinical activity.
|
21508506 |
2011 |
Rheumatoid Arthritis
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that CD28 and ICOS genes may be associated with a risk of RA in Koreans.
|
20113255 |
2010 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Altogether these results demonstrate a pattern of additive effects in NKR-mediated functional modulation of CD4(+)CD28(-) T cells in RA.
|
19904767 |
2010 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
|
20453842 |
2010 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
CTD_human |
Genetic variants at CD28, PRDM1 and CD2/CD58 are associated with rheumatoid arthritis risk.
|
19898481 |
2009 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
A senescent CD4(+)CD28(-) T cell subset develops with aging and in chronic inflammatory diseases like rheumatoid arthritis, and is implicated in plaque rupture and myocardial infarctions.
|
19394279 |
2009 |
Rheumatoid Arthritis
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Fibroblast-like synoviocytes (FLS) and T cells can activate each other in vitro, and in vivo interactions between these cells may be important in rheumatoid arthritis (RA), yet FLS lack significant expression of CD28 ligands.
|
18292521 |
2008 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
Rheumatoid arthritis (RA) is characterized by premature immune aging with accumulation of degenerate T cells deficient for CD28.
|
17675524 |
2007 |
Rheumatoid Arthritis
|
0.500 |
Biomarker
|
disease |
BEFREE |
The latter has gained momentum along with the reported expansion of peripheral CD4(+)CD28(-)NKG2D(+) T cells in rheumatoid arthritis (RA).
|
17565371 |
2007 |