|
Primary biliary cirrhosis
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
This is the first study to demonstrate that POGLUT1 and not CD80 is the effector gene regulated by the primary functional SNP rs2293370, and that increased expression of POGLUT1 might be involved in the pathogenesis of PBC.
|
30643196 |
2019 |
|
Primary biliary cirrhosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
Because activated T cells target the intrahepatic bile ducts in PBC and pre-clinical models suggested that blocking CD80/CD86 with CTLA-4 Ig might have therapeutic benefit in PBC, we performed an open-label trial to determine if CTLA-4 Ig (abatacept) is safe and potentially efficacious in PBC patients with an incomplete response to UDCA.
|
31027870 |
2019 |
|
Primary biliary cirrhosis
|
0.330 |
Biomarker
|
disease |
BEFREE |
Among 21 non-HLA susceptibility loci for PBC identified in GWASs of individuals of European descent, three loci (IL7R, IKZF3, and CD80) showed significant associations (combined p = 3.66 × 10(-8), 3.66 × 10(-9), and 3.04 × 10(-9), respectively) and STAT4 and NFKB1 loci showed suggestive association with PBC (combined p = 1.11 × 10(-6) and 1.42 × 10(-7), respectively) in the Japanese population.
|
23000144 |
2012 |
|
Primary biliary cirrhosis
|
0.330 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
|
21399635 |
2011 |
|
Celiac Disease
|
0.310 |
Biomarker
|
disease |
CTD_human |
Multiple common variants for celiac disease influencing immune gene expression.
|
20190752 |
2010 |
|
Celiac Disease
|
0.310 |
Biomarker
|
disease |
BEFREE |
CD80 (B7-1) and CD86 (B7-2) genes and genetic susceptibility to coeliac disease.
|
12121279 |
2002 |
|
Vitiligo
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo.
|
22561518 |
2012 |
|
Biliary cirrhosis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
|
21399635 |
2011 |
|
Secondary Biliary Cholangitis
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
|
21399635 |
2011 |
|
Biliary Cirrhosis, Primary, 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
|
21399635 |
2011 |
|
Glioma
|
0.220 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the effects of BB-102-based vaccine on glioma in vivo.
|
24408016 |
2014 |
|
Glioma
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
In contrast to CD80 (B7.1) and CD86 (B7.2), ICOSL protein and mRNA was expressed in 7 of 12 glioma cell lines.
|
14603470 |
2003 |
|
Glioma
|
0.220 |
Biomarker
|
disease |
RGD |
Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells.
|
10078962 |
1999 |
|
Periodontal Diseases
|
0.210 |
AlteredExpression
|
group |
BEFREE |
Confocal microscopic analyses revealed that gingival epithelial cells (GEC) from tissue with periodontal disease express both HLA-DR and B7-1 (CD80) costimulatory molecules.
|
15664948 |
2005 |
|
Periodontal Diseases
|
0.210 |
Biomarker
|
group |
RGD |
Requirement of B7 costimulation for Th1-mediated inflammatory bone resorption in experimental periodontal disease.
|
10657664 |
2000 |
|
Kidney Failure
|
0.200 |
Biomarker
|
disease |
RGD |
Valsartan inhibited the accumulation of dendritic cells in rat fibrotic renal tissue.
|
16893502 |
2006 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.200 |
Biomarker
|
disease |
RGD |
Development of human T-cell leukemia virus type 1-transformed tumors in rats following suppression of T-cell immunity by CD80 and CD86 blockade.
|
10590132 |
2000 |
|
Anti-Basement Membrane Glomerulonephritis
|
0.200 |
Biomarker
|
disease |
RGD |
CD28-B7 blockade prevents the development of experimental autoimmune glomerulonephritis.
|
10712436 |
2000 |
|
Malignant Glioma
|
0.200 |
Biomarker
|
disease |
RGD |
Regression of intracerebral rat glioma isografts by therapeutic subcutaneous immunization with interferon-gamma, interleukin-7, or B7-1-transfected tumor cells.
|
10078962 |
1999 |
|
Experimental Autoimmune Encephalomyelitis
|
0.200 |
Biomarker
|
disease |
RGD |
Differential effects of B7-1 blockade in the rat experimental autoimmune encephalomyelitis model.
|
9379015 |
1997 |
|
Lupus Erythematosus, Systemic
|
0.150 |
Biomarker
|
disease |
BEFREE |
Here we investigated whether selective blockade of CD28-CD80/86 co-stimulatory interactions abrogates lupus nephritis development in a murine model of SLE.
|
28631301 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.150 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide search followed by replication reveals genetic interaction of CD80 and ALOX5AP associated with systemic lupus erythematosus in Asian populations.
|
25862617 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.150 |
GeneticVariation
|
disease |
BEFREE |
Single nuclear polymorphism rs2222631 was found associated with SLE with genome-wide significance (P_all=4.5E-08, OR=0.86) and is independent of rs6804441 in CD80, whose association was reported previously.
|
25862617 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.150 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.150 |
GeneticVariation
|
disease |
GWASDB |
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.
|
23273568 |
2013 |