CD80, CD80 molecule, 941

N. diseases: 233; N. variants: 5
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE To explore this possibility, both adenocarcinoma and melanoma human cells were engineered to express both CD80 and CD86 costimulatory molecules. 31161312 2019
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Functionality assays were performed using PD-L1- and CD80-transfected melanoma cells endogenously expressing CSPG4. 29704887 2018
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Lymphocytes from cultures stimulated with CD80 demonstrated cytotoxicity against recipient-untransfected melanoma (45-75% specific lysis at an E:T ratio of 50:1). 17453965 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE The melanoma microenvironment may lead to local T cell tolerance in part through downregulation of costimulatory molecules, such as B7.1 (CD80). 15937544 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Additionally, autologous lymphocytes proliferated in response to CD80-expressing primary uveal melanomas, indicating that this patient group is suitable for immunotherapy. 12709016 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease LHGDN On the biological relevance of MHC class II and B7 expression by tumour cells in melanoma metastases. 12569387 2003
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE In order to construct an immunogenic cellular vaccine, we transduced three HLA-A*0201 human melanoma lines, selected for expression of classes I and II HLA, adhesion molecules and the T cell-defined melanoma antigens Melan/MART-1, gp100 and tyrosinase, with both interleukin-2 (IL-2) and B7-1 genes by the use of a polycistronic retroviral vector. 11459172 2001
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE In order to develop B7-1 gene transfer as a therapeutic tool in the clinical management of melanoma, efficient means of in vivo gene transfer must be used. 9690457 1998
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE We have transfected the B7-1 gene into three HLA-A2-expressing human melanoma cell lines, and studied their capacity to stimulate primary human T cells. 9551360 1998
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Key words: Melanoma; T cells; B7-1 costimulatory molecule (CD80); major histocompatibility complex. 8725884 1996
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE To see whether expression of B7 may render human melanoma cells able to stimulate T cells, a cloned melanoma line (Me1B6), which did not express B7-1, was transfected with the human B7-1 gene. 7589065 1995
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Expression of CD80 (B7.1), by transfecting a CD80 cDNA into the melanoma cell line SkMel63, improved T cell proliferation considerably. 8652275 1995