|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Deleted in Colorectal Cancer (DCC), the receptor for the multifunctional cue netrin-1, acts as a tumor suppressor in intestinal cancer and lung metastasis by triggering cancer cell death when netrin-1 is lowly expressed.
|
31806640 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, the findings of the present study highlight a novel role for netrin‑1 in tumor development under hypoxia in NSCLC and provide further evidence for the use of netrin‑1 as a therapeutic target.
|
30968155 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In multiple animal models, interference with netrin-1 is associated with inhibition of tumor growth and metastasis.
|
31088838 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>In vivo</i> USMI of netrin-1 was validated in nude mice bearing human netrin-1-positive SKBR7 tumors or weakly netrin-1-expressing MDA-MB-231 tumors using the Vevo 2100 small animal imaging device (VisualSonics).
|
30429890 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Xenograft analysis using GC cells revealed that NTN1 overexpression promoted tumor growth.
|
30106432 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Semaphorin 3F and Netrin-1: The Novel Function as a Regulator of Tumor Microenvironment.
|
30532711 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In glioblastoma tumor biopsies netrin-1 localized to hypoxic tumor areas known to be rich in the stem-like cells.
|
28069038 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Since these properties are essential for tumor development, Netrin-1 and its receptors have been reported to promote tumorigenesis in many types of cancers.
|
28443497 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Public databases contain extensive information regarding the expression of NEO1 and its ligands Netrin-1 (NTN1) and Netrin-4 (NTN4) in primary neuroblastoma (NB) tumors.
|
28038459 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Overexpression of netrin-1 in ovarian cancer cells with forced SOX6 expression remarkably abrogated the inhibitory effect of SOX6 on proliferation, invasion of the cells, and tumor xenograft growth and vascularity in vivo.
|
28475012 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Netrin-1 knockdown reduced cell proliferation and attenuated tumor growth in a xenograft mouse model.
|
28710382 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Netrin-1, an axon guidance molecule, has been found in several tumors in adults.
|
27651158 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We review here recent advances in the netrin-1 related developmental processes that may be of special interest in tumor biology, in addition to the known functions of netrin-1 in tumor biology with special focus on cancer cell migration.
|
27793362 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunohistochemical analyses showed that netrin-1 was elevated in medulloblastoma tumors versus cerebellum controls.
|
24812271 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of UNC5B in tumor tissues was significantly downregulated compared to the corresponding normal tissues in which netrin-1 was upregulated.
|
23526078 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, in a model of xenografted nude mice, we show that systemic Doxorubicin treatment triggers netrin-1 upregulation in the tumour but not in normal organs, enhancing and prolonging tumour growth inhibiting effect of a netrin-1 interfering drug.
|
24293316 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, ΔN-netrin-1 stimulated cell proliferation in vitro and tumor growth in vivo.
|
22871610 |
2012 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Increased NTN1 mRNA levels correlated with advanced tumor stage (stage III, n=8, 100%) and grade (grade 3, n=7, 100%).
|
21789787 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that autocrine production of netrin-1, a multifunctional laminin-related molecule, conveys a selective advantage in tumor growth and dissemination in aggressive NB, as it blocks the proapoptotic activity of the UNC5H netrin-1 dependence receptors.
|
19349462 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Netrin-1 receptors might act as a tumor suppressor in colorectal cancers, and thus methylation might present a malignant potential in colorectal cancer.
|
19242752 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The effect of netrin-1 interference on tumor growth was analyzed by DCC-5Fbn intratumoral or netrin-1 siRNA intraperitoneal injection in mice engrafted with lung cancer cell lines.All statistical tests were two-sided.
|
19211441 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, netrin-1 up-regulation, which is associated with tumor formation in mice, is observed in mouse colonic crypts in response to NF-kappaB activation but also in a mouse model of inflammation-induced colorectal cancer.
|
18692059 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer.
|
18353983 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, DCC came back to the spotlight as a better understating of its function and relationship with its ligand (netrin-1) had shown that DCC may act as a conditional tumor-suppressor gene.
|
17018594 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Firstly identified as a tumor suppressor gene in human colorectal carcinomas, the main function for DCC has been described in the nervous system as part of a receptor complex for netrin-1.
|
16762451 |
2006 |