|
Malignant neoplasm of breast
|
0.340 |
Biomarker
|
disease |
BEFREE |
These data suggest that targeting of the novel miR-937-FOXQ1 axis is an attractive therapeutic method against breast cancer.
|
31417280 |
2019 |
|
Breast Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
These data suggest that targeting of the novel miR-937-FOXQ1 axis is an attractive therapeutic method against breast cancer.
|
31417280 |
2019 |
|
Malignant neoplasm of breast
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Moreover, an inverse association was observed between FoxQ1 and DACH1 gene expression in breast cancer cell lines and tumors.
|
27129776 |
2016 |
|
Malignant neoplasm of breast
|
0.340 |
Biomarker
|
disease |
CTD_human |
Expression profiling for cancer stem cell-related genes suggested that FoxQ1 may negatively regulate the expression of Dachshund homolog 1 (DACH1), whose expression is lost in invasive breast cancer.
|
27129776 |
2016 |
|
Breast Carcinoma
|
0.340 |
Biomarker
|
disease |
CTD_human |
Expression profiling for cancer stem cell-related genes suggested that FoxQ1 may negatively regulate the expression of Dachshund homolog 1 (DACH1), whose expression is lost in invasive breast cancer.
|
27129776 |
2016 |
|
Breast Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
Moreover, an inverse association was observed between FoxQ1 and DACH1 gene expression in breast cancer cell lines and tumors.
|
27129776 |
2016 |
|
Malignant neoplasm of breast
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our findings highlight the feasibility of cross-species expression profiling as a strategy to identify metastasis-related genes, and they reveal that EMT induction is a likely mechanism underlying a novel metastasis-promoting function of Foxq1 defined here in breast cancer.
|
21285253 |
2011 |
|
Malignant neoplasm of breast
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
FOXQ1 expression was correlated with high-grade basal-like breast cancers and was associated with poor clinical outcomes.
|
21346143 |
2011 |
|
Breast Carcinoma
|
0.340 |
AlteredExpression
|
disease |
BEFREE |
In this study, we defined a critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells.
|
21346143 |
2011 |
|
Breast Carcinoma
|
0.340 |
Biomarker
|
disease |
BEFREE |
Our findings highlight the feasibility of cross-species expression profiling as a strategy to identify metastasis-related genes, and they reveal that EMT induction is a likely mechanism underlying a novel metastasis-promoting function of Foxq1 defined here in breast cancer.
|
21285253 |
2011 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.
|
27129776 |
2016 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.
|
27129776 |
2016 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Forkhead Box Q1 Is a Novel Target of Breast Cancer Stem Cell Inhibition by Diallyl Trisulfide.
|
27129776 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
High FOXQ1 expression is associated with advanced tumor features as well as undesirable survival profiles in patients with NSCLC, implying the potential prognostic value of FOXQ1 for NSCLC.
|
31713908 |
2020 |
|
Neoplasm Metastasis
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of FOXQ1 was observed in 63.24% of PTC and correlated with classic variant, tall variant, distant metastasis, AJCC stage and recurrence.
|
30378716 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
FOXF2 and FOXQ1, forkhead box transcription factor superfamily members, are encoded by neighboring genes located on human chromosome 6p25.3 and play opposite roles in epithelial-mesenchymal transition (EMT) and metastasis in basal-like breast cancer (BLBC).
|
30807702 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Forkhead box Q1 (FOXQ1), a member of the forkhead transcription factor family, plays important parts in cell cycle, apoptosis, metabolism, immunology and tumour genesis.
|
30378716 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, overexpression of FOXQ1 could partially rescue inhibitory effect of miR-342-3p on cell migration and invasion in OC.
|
31517731 |
2019 |
|
Tumor Cell Invasion
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
miR-342-3p downregulation predicts poor prognosis in NPC patients and shows suppressive activity against NPC growth and invasion through repression of FOXQ1.
|
30678643 |
2019 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
FOXQ1 affected the initiation, progression, invasion, and metastasis of many kinds of tumor by promoting the epithelial-mesenchymal transition, regulating cell cycle, promoting cell proliferation, regulating senescence-associated inflammation, and activating many cellular signal pathways.
|
29516951 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
LncRNA MALAT1 promotes tumor growth and metastasis by targeting miR-124/foxq1 in bladder transitional cell carcinoma (BTCC).
|
29736319 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, we have characterized FOXQ1 as a melanoma tumor suppressor that acts via repression of N-cadherin gene, and invasion and metastasis.
|
29463842 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Intriguingly, pSTAT6/C-C motif chemokine ligand 26 (CCL26) signaling is induced by FOXQ1/NDRG1 axis, thus recruiting hepatic stellate cells (HSCs), the main cellular source of CAFs, to the tumor microenvironment.
|
29248714 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Medline literature review related to this subject was performed by the electronically retrieval with the keywords "forkhead box Q1" and "tumor" on PubMed for including previous publications, and then, it further reviewed reference articles on the biological function of FOXQ1 gene and target genes transcription directly regulated by FOXQ1.
|
29516951 |
2018 |
|
Neoplasm Metastasis
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
These integrated efforts have identified FOXQ1 as a tumor promoter and might provide promising approaches for colorectal cancer metastasis treatment.
|
28559972 |
2017 |