|
Acoustic Neuroma
|
0.010 |
Biomarker
|
disease |
BEFREE |
BCRP is present in the vasculature of vestibular schwannomas, plexiform neurofibromas and MPSNT.
|
29179472 |
2017 |
|
Acute leukemia
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that these highly prevalent ABCG2 34GA/AA genotypes are associated with poor prognosis of Chinese patients with acute leukaemia and BMT patients.
|
21531129 |
2011 |
|
Acute leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Expression of breast cancer resistance protein in blast cells from patients with acute leukemia.
|
10891476 |
2000 |
|
Acute leukemia
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
No differences between expression of P-gp and BCRP and genes in primary and relapsed acute leukemia (AL) cells as well as in de novo and treated CLL samples were established.
|
19635183 |
2009 |
|
Acute leukemia
|
0.040 |
Biomarker
|
disease |
BEFREE |
Multidrug resistance (MDR), which is mediated by multiple drug efflux ATP-binding cassette (ABC) transporters, is a critical issue in the treatment of acute leukemia, with permeability glycoprotein (P-gp), multidrug resistance-associated protein 1, and breast cancer resistance protein (i.e., ABCG2) consistently being shown to be key effectors of MDR in cell line studies.
|
22826468 |
2012 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We studied blast cells from 21 acute leukemia patients (20 acute myeloid leukemia, 1 acute lymphocytic leukemia) for the expression of BCRP mRNA using a quantitative reverse-transcription polymerase chain reaction assay.
|
10891476 |
2000 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Infants expressed 2.4-fold less BCRP mRNA (P=0.009) than non-infants with ALL.
|
14574327 |
2004 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Real-time PCR results showed that expression level of MDR1 was significantly higher in AML whereas expression of DHFR, BCRP and Survivin was significantly higher in ALL patients.
|
22037714 |
2012 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The role of ABC-transporter gene polymorphisms in chemotherapy induced immunosuppression, a retrospective study in childhood acute lymphoblastic leukaemia.
|
17434155 |
2006 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The expressions of ABCB1 and ABCG2 genes were regulated through MAPK/ERK and JNK pathways in the human ALL cell lines.
|
24324065 |
2013 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No relationship was found between of MVP/LRP, MRP3 and ABCG2 genes expression and ALL prognoses.
|
24145140 |
2014 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found significantly lower expression of the reduced folate carrier (SLC19A1, an MTX uptake transporter) in E2A-PBX1 ALL, significantly higher expression of breast cancer resistance protein (ABCG2, an MTX efflux transporter) in TEL-AML1 ALL, and lower expression of FPGS (which catalyzes formation of MTXPG) in T-lineage ALL, consistent with lower MTXPG accumulation in these ALL subtypes.
|
15630450 |
2005 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate their possible roles in disease susceptibility and some disease characteristics we genotyped C3435T and G2677T/A polymorphisms in multidrug resistance-1 (MDR1) gene with a single base extension method and the G34A and C421A polymorphisms of the breast cancer resistance protein gene with an allelic discrimination system in 396 children with acute lymphoblastic leukaemia (ALL) and 192 control patients.
|
18243305 |
2008 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The ABCB1 and ABCG2 gene expression levels were analyzed using real-time polymerase chain reaction in 61 patients diagnosed with ALL and 99 healthy donors as controls.
|
27960630 |
2017 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Poor correlations between mRNA, protein and function indicate the complex biology of BCRP in adult ALL, and the possible correlation of BCRP expression with DFS should be studied in larger series.
|
15521915 |
2004 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the MTHFR 677TT associated with the ABCG2 421GT + TT variant more significantly reduced the risk of adult ALL (OR = 0.32; 95% CI 0.12-0.85).
|
21657963 |
2011 |
|
Acute lymphocytic leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
No significant difference in expression of BCRP mRNA was measured between initial-stage and relapsed-stage ALL or between normal MNC obtained from BM and ALL patients.
|
12100141 |
2002 |
|
Acute Megakaryocytic Leukemias
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Samples from children with acute megakaryoblastic leukemia (AML FAB-M7) not associated with Down syndrome showed uniformly higher levels of ABCG2 transcripts than samples from children with other AML subtypes.
|
21640380 |
2011 |
|
Acute monocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
AML sample BCRP mRNA levels were between those in parental 8226 and 35-fold mitoxantrone-resistant 8226/MR20 cells in all but one case, and BCRP mRNA had the wild-type sequence at codon 482 in all.
|
15208643 |
2004 |
|
Acute monocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
ABCG2 was expressed at higher levels in subtypes of AML with favorable outcome but within standard- and high-risk patients, it was associated with poor outcome (P = 0.02).
|
26512967 |
2016 |
|
Acute monocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
ABCG2 and CD200 define patients at high risk of relapse in ELN favorable subgroup of AML.
|
28618016 |
2017 |
|
Acute monocytic leukemia
|
0.050 |
Biomarker
|
disease |
BEFREE |
Recently, the breast cancer-resistant protein (BCRP), the equivalent of mitoxantrone-resistant protein (MXR) or placental ABC transporter (ABCP), was described in AML.
|
11986944 |
2002 |
|
Acute monocytic leukemia
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
ABC transporter expression in hematopoietic stem cells and the role in AML drug resistance.
|
17368038 |
2007 |
|
Acute myeloid leukaemia refractory
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Increased expression of the breast cancer resistance protein (BCRP) in relapsed or refractory acute myeloid leukemia (AML).
|
11986944 |
2002 |
|
Adenocarcinoma
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Our findings show that ABCG2 rs3114020 might be one of the candidate biomarkers for NSCLC survival in this Chinese population, especially among patients with adenocarcinoma.
|
26951883 |
2017 |