Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30, which is positive for anaplastic large cell lymphoma (Ki-1 lymphoma), was not expressed. 2004329 1991
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE A CD30-positive T cell line established from an aggressive anaplastic large cell lymphoma, originally diagnosed as Hodgkin's disease. 8035614 1994
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE We report here the establishment of a CD30 (Ki-1) antigen-positive cell line 'Ki-JK' from a child with anaplastic large cell lymphoma. 8169113 1993
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE The t(2;5) chromosomal translocation is not a common feature of primary cutaneous CD30+ lymphoproliferative disorders: comparison with anaplastic large-cell lymphoma of nodal origin. 8605362 1996
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE The fourth case had a subpopulation of CD30 positive cells but also did not have morphological features of anaplastic large cell lymphoma. 8666370 1996
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30(+) anaplastic large-cell lymphoma in children: analysis of 82 patients enrolled in two consecutive studies of the French Society of Pediatric Oncology. 9808552 1998
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE Sinusoidal CD30-positive large B-cell lymphoma: a morphologic mimic of anaplastic large cell lymphoma. 10757332 2000
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30(+) anaplastic large cell lymphoma: a review of its histopathologic, genetic, and clinical features. 11090048 2000
Childhood Anaplastic Large Cell Lymphoma
0.100 GeneticVariation disease BEFREE Primary CD30/Ki-1 positive anaplastic large cell lymphoma of skeletal muscle with der(17)t(1;17)(q11;p11). 11106821 2000
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE Differential effects of CD30 activation in anaplastic large cell lymphoma and Hodgkin disease cells. 11110706 2000
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE However, CD13 positivity has not previously been described in a case of CD30+ (ALK-1+) anaplastic large-cell lymphoma of presumed null-cell origin without histiocytic differentiation. 11138613 2000
Childhood Anaplastic Large Cell Lymphoma
0.100 AlteredExpression disease BEFREE CD30-mediated cell cycle arrest associated with induced expression of p21(CIP1/WAF1) in the anaplastic large cell lymphoma cell line Karpas 299. 11313991 2001
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30, however, is not a specific marker of anaplastic large cell lymphoma and has been found to be expressed in reactive as well as neoplastic populations as a probable activation marker. 11473453 2001
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30 mAbs have been shown to be effective in in vitro and in vivo models of hematologic malignancies such as anaplastic large cell lymphoma, yet these mAb have not been efficacious in HD models. 12097283 2002
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE In conclusion, the presence of CD30-positive atypical lymphoid cells in 71.4% of the common nonneoplastic cases studied, even in the presence of clonal B-cell populations, warrants caution in the interpretation of these cells as malignant, particularly when dealing with the differential diagnosis of lymphomatoid papulosis or neutrophil-rich anaplastic large cell lymphoma. 12826883 2003
Childhood Anaplastic Large Cell Lymphoma
0.100 AlteredExpression disease BEFREE CD30-induced up-regulation of the inhibitor of apoptosis genes cIAP1 and cIAP2 in anaplastic large cell lymphoma cells. 15050749 2004
Childhood Anaplastic Large Cell Lymphoma
0.100 AlteredExpression disease BEFREE c-Kit receptor (CD117) is expressed by erythroid, megakaryocytic, and myeloid precursors and mature mast cells and has been reported to be expressed in CD30+ lymphomas such as Hodgkin's disease and anaplastic large-cell lymphoma. 15105813 2004
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30 staining is observed in most cases, but is weaker and less homogeneous than in classic Hodgkin's lymphoma or anaplastic large cell lymphoma. 15202521 2003
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE Signal transduction in anaplastic large cell lymphoma cells (ALCL) mediated by the tumor necrosis factor receptor CD30. 15291361 2004
Childhood Anaplastic Large Cell Lymphoma
0.100 AlteredExpression disease BEFREE SGN-30, a monoclonal antibody with activity against CD30+ malignancies, is currently in phase II clinical evaluation for treatment of Hodgkin's disease (HD) and anaplastic large cell lymphoma. 16049514 2005
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE Stimulation of CD30 in anaplastic large cell lymphoma leads to production of nuclear factor-kappaB p52, which is associated with hyperphosphorylated Bcl-3. 16108830 2005
Childhood Anaplastic Large Cell Lymphoma
0.100 PosttranslationalModification disease BEFREE JunB induced by constitutive CD30-extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase signaling activates the CD30 promoter in anaplastic large cell lymphoma and reed-sternberg cells of Hodgkin lymphoma. 16140928 2005
Childhood Anaplastic Large Cell Lymphoma
0.100 AlteredExpression disease BEFREE mRNA expression patterns indicate CD30 mediated activation of different apoptosis pathways in anaplastic large cell lymphoma but not in Hodgkin's lymphoma. 16198418 2006
Childhood Anaplastic Large Cell Lymphoma
0.100 AlteredExpression disease BEFREE The expression of CD30 in anaplastic large cell lymphoma is regulated by nucleophosmin-anaplastic lymphoma kinase-mediated JunB level in a cell type-specific manner. 16982741 2006
Childhood Anaplastic Large Cell Lymphoma
0.100 Biomarker disease BEFREE CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells. 17261581 2007