|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
Genetic influences on susceptibility to rheumatoid arthritis in African-Americans.
|
30423114 |
2019 |
|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
|
Rheumatoid Arthritis
|
0.170 |
Biomarker
|
disease |
BEFREE |
Furthermore, we performed GFP-LC3 punctate fluorescence dot assays and western blotting (for LC3, ATG5, p62, and Beclin 1) to assess autophagy in RA-FLS.
|
31820689 |
2019 |
|
Rheumatoid Arthritis
|
0.170 |
Biomarker
|
disease |
BEFREE |
The results showed that the expression of autophagy related LC3 protein was up-regulated with lower lysosomal pH in neutrophils from synovial fluid of RA and changed under stimulation of CQ and small RNA interferences (siRNAs) Atg5 transfection, which proved in acute promyelocytic leukemia HL-60 cell lines, predominantly a neutrophilic promyelocyte, treated by plasma and synovial fluid from RA.
|
30312880 |
2018 |
|
Rheumatoid Arthritis
|
0.170 |
Biomarker
|
disease |
BEFREE |
We studied 393 patients with rheumatic diseases, including ankylosing spondylitis (ASP, n = 90), rheumatoid arthritis (RA; n = 120), psoriatic arthritis (PA, n = 126), and other disorders (n = 57).
|
29735171 |
2018 |
|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
|
27193031 |
2017 |
|
Rheumatoid Arthritis
|
0.170 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the expression levels (both in mRNA and in protein level) of autophagy-related proteins (belcin1, Atg5, and LC3) in the synovial tissue of patients with active rheumatoid arthritis (<i>n</i> = 20) were significantly higher than those in OA patients (<i>n</i> = 16).
|
28255205 |
2017 |
|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
GWASCAT |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
GWASDB |
Genetics of rheumatoid arthritis contributes to biology and drug discovery.
|
24390342 |
2014 |
|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
Our results showed no involvement of rs548234 at PRDM1-ATG5 region in the susceptibility or clinical relevance of RA in Chinese Han population.
|
22040493 |
2011 |
|
Rheumatoid Arthritis
|
0.170 |
Biomarker
|
disease |
BEFREE |
Two other SNPs, mapping to ATG5 and KIAA1542, showed nominal evidence for association with RA (p=0.02 and p=0.02, respectively) but these were not significant after applying a Bonferroni correction.
|
21068098 |
2011 |
|
Rheumatoid Arthritis
|
0.170 |
GeneticVariation
|
disease |
BEFREE |
The protective genotype, present in 41% of controls, was less frequent in RA patients: 33% in the first sample, 24% in the ASP RA sample, and 11% in the linkage-derived subgroup.
|
14872483 |
2004 |