|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Further investigation on mechanism of action indicated that compound 11x could inhibit colorectal cancer growth through ATG5-depenent autophagy pathway.
|
31181480 |
2019 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Taken together, our findings suggest that hypoxia-mediated autophagy was regulated by miR-20a/ATG5/FI200 signaling pathway in CRC. miR-20a-mediated autophagy defect that might play an important role in hypoxia-induced autophagy during colorectal tumorigenesis.
|
30883936 |
2019 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
miR-183-5p enhances the radioresistance of colorectal cancer by directly targeting ATG5.
|
31502570 |
2019 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Knockdown of ATG5 (which disrupts autophagosome elongation) or RAB21 (which decreases autophagosome/lysosome fusion) had little effect on CRC cell proliferation in vitro.
|
31383875 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
BEFREE |
HBV: hepatitis B virus; HCC hepatocellular carcinoma; TNFSF10: tumor necrosis factor superfamily member 10; ATG5: autophagy-related protein 5; DNA: deoxyribonucleic acid; LDR-PCR: ligase detection reactions-polymerase chain reaction; PCR: polymerase chain reaction; SLE: systemic lupus erythematosus; BD: Behçet's disease; IL-10: interlukin-10; LPS: lipopolysaccharide; PBMC: peripheral blood mononuclear cells; CWP: coal workers' pneumoconiosis; TNF-α: tumor necrosis factor-α.
|
30907204 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis reveals shared new loci in systemic seropositive rheumatic diseases.
|
30573655 |
2019 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to verify if ATG5 polymorphisms are involved in the susceptibility to disease and its clinical phenotypes in an Italian cohort of SLE patients.
|
29759048 |
2018 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
A combined large-scale meta-analysis identifies COG6 as a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus.
|
27193031 |
2017 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Transancestral mapping and genetic load in systemic lupus erythematosus.
|
28714469 |
2017 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Specific inhibition of autophagy by 3-MA or shRNA targeting Atg5 rescued Sal B-induced cell death in vitro and in vivo, suggesting that Sal B-induced autophagy may play a pro-death role and contribute to the cell death of colorectal cancer cell lines.
|
27557491 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus.
|
27399966 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
BEFREE |
With several single nucleotide polymorphisms (SNPs) in autophagy-related gene5 (ATG5) being linked to SLE susceptibility, more and more lines of evidence from animal model, cell biology, immunology, and genetics studies show that autophagy contributes to the occurrence, development, and severity of SLE.
|
27673477 |
2016 |
|
Lupus Erythematosus, Systemic
|
0.390 |
Biomarker
|
disease |
BEFREE |
Autophagy-related gene 5 (ATG5), ATG7, B-lymphoid tyrosine kinase (BLK) and B-cell scaffold protein with ankyrin repeats 1 (BANK1) are involved in B-cell signaling; several genome-wide association studies detected these genes as candidates involved in systemic lupus erythematosus (SLE).
|
26420661 |
2016 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
To investigate whether ATG5 deficiency could sensitize tumors to chemotherapies, we compared the antitumor effects of Interferon-gamma (IFN-γ) between Apc(Min/+)ATG5(+/+) and Apc(Min/+)ATG5(+/-) mice, as IFN-γ is a potential tumor suppressor for CRC and has been used clinically as an efficient adjuvant to chemotherapy of cancer.
|
25695667 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Although these rare variants were observed to be located in the flanking regions of exons instead of missense mutations, patients carrying them tended to have severe clinical phenotype, and in silicon analysis suggested their regulatory effects.Increased frequencies of rare variants of ATG5 were identified in patients with LN and SLE compared with healthy controls, highlighting a likely important role of rare ATG5 variants in Chinese SLE patients.
|
26039132 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
Correlations between the trans-eSNPs and ATG5 expression and different expression levels of ATG5 in SLE patients and controls were validated, and their regulatory effects were annotated.
|
26509176 |
2015 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus.
|
26502338 |
2015 |
|
Colorectal Carcinoma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In contrast, codon 12 or 13 GLY>ASP substitutions (resulting in a G>A transition) were more frequent in CRC (42%) compared with NSCLC (21%).
|
24331409 |
2014 |
|
Lupus Erythematosus, Systemic
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
First, we detected the expression of autophagy-related genes (Atg5, Atg12 and Beclin 1) in the macrophages derived from activated lymphocytes-derived DNA (ALD-DNA) induced murine lupus as well as in the PBMC from SLE patients.
|
25151985 |
2014 |
|
Colorectal Carcinoma
|
0.390 |
AlteredExpression
|
disease |
BEFREE |
ASP was upregulated in CRC tissues, and greater activity correlated significantly with the absence of lymph node metastases and with better overall survival.
|
23948443 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the Atg5 rs573775 T* allele seems to influence SLE susceptibility, cytokine production and disease features depending on other factors such as functional IL-10 genotype.
|
24205307 |
2013 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.
|
23740937 |
2013 |
|
Colorectal Carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
To investigate the clinicopathological role of ATG5 in colorectal cancer, we firstly investigated its expression in patients with sporadic colorectal cancer.
|
22993366 |
2012 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Genetic association of PRDM1-ATG5 intergenic region and autophagy with systemic lupus erythematosus in a Chinese population.
|
21622776 |
2011 |
|
Lupus Erythematosus, Systemic
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.
|
19838193 |
2009 |