|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD36 is a key mediator of fatty acid uptake in skeletal muscle, linking obesity with satellite cell function and muscle regeneration.
|
31599493 |
2020 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Moreover, FATP4 and CD36 expression levels correlated with measures of obesity and insulin resistance that are influenced by both genetic and non-genetic factors (FATP4 versus BMI: r=0.53, p=0.0001; FATP4 versus body fat: r=0.51, p=0.002; FATP4 versus homeostasis model assessment [HOMA]: r=0.49, p=0.001; CD36 versus BMI: r=0.50, p=0.02; CD36 versus body fat: r=0.63, p=0.001; CD36 versus HOMA: r=0.34, p=0.06).
|
15168018 |
2004 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Accordingly, mitochondrial expression of FAT/CD36 and plasma membrane fatty acid-binding protein was decreased in both groups of subjects with obesity.
|
30724038 |
2019 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our study reveals that absence of TIMP4 can impair lipid absorption and the high fat diet-induced obesity in mice possibly by regulating the proteolytic processing of CD36 protein in the intestinal enterocytes.
|
28740132 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD36 is a scavenger and antiangiogenic receptor that is important in atherothrombotic diseases, diabetes mellitus, cancer, and obesity.
|
27013613 |
2016 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The expression of pyruvate dehydrogenase kinase 4 (PDK4) and the fatty acid transporter CD36 increased in both LN and OB during HF.
|
22253914 |
2012 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
CD36 promoter SNP allele -22674C is therefore associated with lower serum low-density lipoprotein-cholesterol in normal female twins and with improved lipid profile during weight loss and maintenance in obese subjects.
|
19016618 |
2008 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Increase in plasma membrane FAT/CD36 content in obese rats and failure in lipin-1 export to nucleus with progression of obesity, implying an increase in FA uptake and their different channeling into lipid intermediates synthesis pathway in old fa/fa rats versus FA usage in lean rats of the same age.
|
28653652 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, mice with the <i>Val66Met</i> variant in both alleles (BDNF<sup>M/M</sup>) fed a high-fat diet exhibited extreme obesity with increased CD36 gene and protein levels in macrophages.
|
29914985 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
This is the first established link between physical binding of fatty acids and a function of CD36, and has implications for obesity and atherosclerosis.
|
27288302 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to evaluate the relationship between the BMIz trajectory versus the percent body fat (%FAT) trajectory, and if BMIz could predict significant changes in %FAT in a sample of obese children and adolescents.
|
29880034 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The purpose of this investigation was to evaluate if BMI could predict total fat mass (TFM) and percent body fat (%FAT) in a sample of overweight and obese children.
|
28577356 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to investigate the association of selected single nucleotide polymorphisms (SNPs) of cluster of differentiation 36 (CD36) and peroxisome proliferator-activated receptor γ (PPARγ) with VPA-induced weight gain and obesity in epileptic patients.
|
29984389 |
2018 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The present study evaluated the association of CD36 variants and the interaction with obesity on type 2 diabetes mellitus (T2DM) risk.
|
29572193 |
2018 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Receptor CD36 links a risk-associated allele to obesity and metabolic disorders.
|
30143599 |
2018 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to determine whether human genetic variation in 5 common CD36 polymorphisms is associated with oral fat perception of Italian salad dressings, self-reported acceptance of high-fat foods and obesity in African-American adults (n = 317).
|
22240721 |
2012 |
|
Obesity
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
We report that rs1761667 polymorphism of CD36 gene and oro-gustatory thresholds for fat might play a significant role in the development of obesity in young teenagers.
|
26556365 |
2015 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
CD36 expression and its relationship with obesity in blood cells from people with and without Prader-Willi syndrome.
|
16451133 |
2006 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
High affinity FA binding to CD36 and the effects of each FA on oxLDL uptake have important implications for protein conformation, binding of other ligands, functional properties of CD36, and high plasma FA levels in obesity and type 2 diabetes.
|
25555908 |
2015 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Overweight involved 3-14% of the participants and obesity was diagnosed in isolated cases (0-3%); both were considerably lower compared to the estimates based on %FAT.
|
28643234 |
2018 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
To assess the relationship between CD36 gene single-nucleotide polymorphisms (SNPs) and obesity in adolescents, we evaluated the relationship between CD36 SNPs and the risk of obesity in a case-control study composed of 307 obese (age = 15.0 +/- 1.1 years) and 339 normal-weight adolescents (age = 14.6 +/- 1.1 years).
|
19893500 |
2010 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Obesity is associated with altered duodenal expression of FFAR1, FFAR4 and CD36, suggesting altered capacity for the sensing, absorption and metabolism, of dietary lipids.
|
27811952 |
2017 |
|
Obesity
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The realization that the transport step rate limits cellular fatty acid utilization suggests that abnormalities in CD36 expression or function may impact on susceptibility to certain metabolic diseases such as obesity and insulin resistance.
|
11844979 |
2002 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
Together these data suggest that limiting FA uptake and partial inhibition of FA oxidation in the heart via CD36 ablation may be detrimental for the compensated hypertrophic heart in the absence of sufficiently elevated circulating FAs to provide an adequate energy source.<b>NEW & NOTEWORTHY</b> Limiting CD36-mediated fatty acid uptake in the setting of obesity and/or insulin resistance protects the heart from cardiac hypertrophy and dysfunction.
|
28062415 |
2017 |
|
Obesity
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD36 is a membrane protein which contributes to the metabolic disorders such as obesity.
|
28712872 |
2017 |