|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results conclude that IL-34 facilitates foam cell formation by increasing CD36-mediated lipid uptake and suggest a potential new risk biomarker for atherosclerosis.
|
30478377 |
2018 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Vim<sup>-/-</sup> mice displayed decreased atherogenesis despite increased vascular inflammation and increased CD36 expression on macrophages in two mouse models of atherosclerosis.
|
30451917 |
2018 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
All of these results demonstrated that FSTL3 as a novelty cytokine takes part in the process of atherosclerosis through increasing lipid accumulation and inflammation through regulating CD36 and LOX-1 expression.
|
31815869 |
2019 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Rcan1 regulates CD36 expression and its genetic inactivation reduced atherosclerosis extension and severity in Apoe(-/-) mice.
|
24127415 |
2013 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our findings indicated that myricetin suppressed cholesterol accumulation in macrophage foam cells by inhibition of CD36-mediated ox-LDL uptake, and suggested myricetin may have an important therapeutic function for atherosclerosis.
|
31049071 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Silencing of either SR-A or CD36 reduces atherosclerosis in hyperlipidaemic mice and reveals reciprocal upregulation of these receptors.
|
20634212 |
2010 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In rodents, CD36 is implicated in abnormal lipid metabolism, inflammation and atherosclerosis.
|
20935172 |
2011 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Macrophage scavenger receptors, such as CD36 and class A scavenger receptor (SR-A), have previously been thought to play a central role in foam cell formation and atherogenesis by mediating the uptake of oxidized LDL.In this issue of the JCI, Moore et al. report that Apoe mice deficient in either CD36 or SR-A did not have less atherosclerosis at the level of the aortic valve than did wild-type Apoe mice.
|
16075051 |
2005 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Scavenger receptor CD36 is associated with increasing risk of diabetes and atherosclerosis, and may play a role in cognitive deficits.
|
28883843 |
2017 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The blocking of autophagy-lysosome induction could increase CD36 protein level, foam-cell formation, and migration, thus abolishing the protective effects of CTRP13 on atherosclerosis.
|
30222079 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Both S100A12 and CD36 are implicated in vascular inflammation and atherosclerosis.
|
28756107 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Recent literature has implicated CD36 in the pathogenesis of metabolic dysregulation such as found in obesity, insulin resistance, and atherosclerosis.
|
21250778 |
2011 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Thus, targeting to CD36 and its downstream effectors may serve as potential new strategies against chronic inflammatory diseases such as atherosclerosis.
|
31625810 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Role of CD36, the macrophage class B scavenger receptor, in atherosclerosis.
|
11795270 |
2001 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Azapeptide analogues of growth hormone-releasing peptide-6 (His-d-Trp-Ala-Trp-d-Phe-Lys-NH<sub>2</sub>, GHRP-6) have for example been pursued as ligands of the cluster of differentiation 36 receptor (CD36) and show promising activity for the development of treatments for angiogenesis-related diseases, such as age-related macular degeneration, as well as for atherosclerosis.
|
28598597 |
2017 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expression of CD36 in macrophages promotes the accumulation of cholesterol, the development of foam cells, and ultimately atherosclerosis.
|
16822947 |
2006 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Blocking Wnt5a signaling decreases CD36 expression and foam cell formation in atherosclerosis.
|
29474941 |
2018 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
We found that allergic asthma increased the expression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the liver and CD36 in the aorta during the acute and advanced stages of atherosclerosis, respectively.
|
31558320 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings indicate that caveolae and CD36 are involved in native LDL endocytosis and suggest that CD36 might be a good candidate for the transport of native LDL across the endothelium, an early event in atherosclerosis.
|
30768959 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
CD36 is associated with regulation of lipid metabolism, atherosclerosis, and blood pressure.
|
31185924 |
2019 |
|
Atherosclerosis
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
To search for associations between the CD36 gene polymorphisms and radiological markers of atherosclerosis progress in Caucasian patients with coronary artery disease (CAD) diagnosed at a young age.
|
22993001 |
2012 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
In hematopoietic cells, CD36 signaling enhances platelet dysfunction thus decreasing the threshold for platelet activation and accelerating arterial thrombosis, whereas in macrophages, CD36 promotes lipid-laden foam cell formation and atherosclerosis.
|
30825500 |
2019 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
Deficiency of CD36 on hematopoietic cells diminished the effect of air pollution on 7-KCh accumulation, foam cell formation, and atherosclerosis.
|
25186795 |
2014 |
|
Atherosclerosis
|
0.300 |
Biomarker
|
disease |
BEFREE |
The present study aimed to explore whether PM<sub>2.5</sub>-exacerbated atherosclerosis was mediated by the cooperation of cluster of differentiation 36 (CD36) and nucleotide-binding oligomerization domain-like receptor protein (NLRP3) inflammasome in apolipoprotein E<sup>-/-</sup> (ApoE<sup>-/-</sup>) mice.
|
29571893 |
2018 |
|
Atherosclerosis
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In understanding the mechanisms of cholesterol in the pathogenesis of atherosclerosis, previous studies from other laboratories have demonstrated that cholesterol crystals (CC) induce scavenger receptor CD36 expression and NLRP3-mediated inflammasome formation.
|
28040583 |
2017 |