Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE A disintegrin-like and metalloproteinase with thrombospondin type-1 motifs-4 (ADAMTS-4) and ADAMTS-5 are zinc-dependent metalloproteinases that are involved in the maintenance of cartilage extracellular matrix (ECM) and are currently considered the major aggrecanases in the development of osteoarthritis. 31463904 2020
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE To examine the susceptibility of fibromodulin (FMOD) and lumican (LUM) to degradation by MMP-13, ADAMTS-4 and ADAMTS-5, the three major degradative proteinases in articular cartilage, in cartilage development and in osteoarthritis (OA). 30700002 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE These findings indicated that AQP1 depletion may decrease ADAMTS‑4 expression in human OA chondrocytes. 29393494 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Using a rabbit model of early-stage osteoarthritis (OA) and a sampling patients with OA, we evaluated the diagnostic utility of a fluorogenic peptide-conjugated gold nanoparticle (AuNP) probe in detecting mild cartilage injury, based on the a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) enzyme. 30210670 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Further, we revealed that Cyr61 could promote OA chondrocyte proliferation through inhibiting ADAMTS-4. 29236314 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Further, Wogonin exhibits potent chondroprotective potential by switching the signaling axis of matrix degradation from catabolic towards anabolic ends and inhibited the expression, production and activities of matrix degrading proteases including MMP-13, MMP-3, MMP-9, and ADAMTS-4 in OA chondrocytes, and blocked the release of s-GAG and COL2A1 in IL-1β-stimulated OA cartilage explants. 28237856 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE We found that the Wogonin containing fraction-4 (F4) was the most potent fraction based on its ability to inhibit ROS production and the suppression of catabolic markers including IL-6, COX-2, iNOS, MMP-3, MMP-9, MMP-13 and ADAMTS-4 in IL-1β-treated OA chondrocytes. 28256567 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE In addition to the well-characterised MMPs, ADAMTS-4 and ADAMTS-5, many other ADAMTSs and ADAMs are expressed in cartilage and several show significantly altered expression in OA. 28216310 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE The results of the present study demonstrated that WIN‑55 inhibited ADAMTS‑4 activity in unstimulated and IL‑1β‑stimulated primary human OA articular chondrocytes in a concentration‑dependent manner. 27082728 2016
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE Both neuropeptides decreased ADAMTS-4, -5, -7 and -12 expressions, aggrecanase activity, glycosaminoglycans (GAG), and cartilage oligomeric matrix protein (COMP) degradation after stimulation with fibronectin fragments (Fn-fs) in OA-SF. 26818776 2016
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Increased serum ADAMTS-4 in knee osteoarthritis: a potential indicator for the diagnosis of osteoarthritis in early stages. 25501175 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Except for interleukin-1β (IL-1β) and CXCL2, the mRNA (messenger RNA) expression of all other chemokine (IL-8, CXCL1, CXCL3, CXCL6, CCL3, and CCL3L1), matrix-degrading (matrix metalloproteinase [MMP]-13 and ADAMTS-4), and structural matrix (COL2A1 [collagen, type II, alpha] and ACAN [aggregan]) genes was higher overall in cartilage from hips with femoroacetabular impingement compared with hips with osteoarthritis and normal controls. 23965695 2013
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE An antibody specific for ADAMTS-4_v1 was found to bind to the synovial membrane surface on cryosections, and the protein was detected in cell lysates from synovium obtained from OA patients. 23897278 2013
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Roles for the proteases in inflammation and atherosclerosis have been suggested by a number of recent studies, and the role of ADAMTS-4 and -5 in the breakdown of aggrecan and subsequent degradation of cartilage during osteoarthritis has also been established. 20652528 2010
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE The mechanisms of ADAMTS-5 activation and their links to the pathogenesis of osteoarthritis remain poorly understood, but syndecans have been shown to be involved in the activation of ADAMTS-4 (ref.3). 19684582 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE These results suggest that ADAMTS-4 is epigenetically regulated and plays a role in aggrecan degradation in human OA. 18941754 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE The overall percentage of non-methylated sites was increased in OA patients (48.6%) compared with controls (20.1%): 20% versus 4% for MMP-13, 81% versus 47% for MMP-9, 57% versus 30% for MMP-3, and 48% versus 0% for ADAMTS-4. 16200590 2005
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 GeneticVariation disease BEFREE Genetic association analysis of the IGFBP7, ADAMTS3, and IL8 genes as the potential osteoarthritis susceptibility that maps to chromosome 4q. 15708897 2005