|
Congestive heart failure
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Four BAG3 genetic variants were identified; these were expressed in 42 of 402 African American individuals (10.4%) with nonischemic heart failure and 9 of 107 African American individuals (8.4%) with ischemic heart failure but were not present in a reference population of European ancestry (P < .001).
|
30140897 |
2018 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
BEFREE |
Taken together, these results suggest that mice in which BAG3 has been deleted from a single allele provide a model that mirrors the biology seen in patients with heart failure and BAG3 haplo-insufficiency.
|
29323723 |
2018 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
BEFREE |
Furthermore, we discuss emerging evidence of increased expression of extracellular HSP70, HSP90 and BAG-3 in heart failure, with complementary independent roles from intracellular functions with important therapeutic and diagnostic considerations.
|
29203715 |
2018 |
|
Congestive heart failure
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
DCM caused by mutations in BAG3 is characterized by high penetrance in carriers >40 years of age and a high risk of progressive heart failure.
|
30442290 |
2018 |
|
Congestive heart failure
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutation and downregulation of the co-chaperone protein BCL-2-associated athanogene 3 (BAG3) are associated with cardiac myopathy and heart failure, and a BAG3 E455K mutation leads to dilated cardiomyopathy (DCM).
|
28737513 |
2017 |
|
Congestive heart failure
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Earlier studies have ascribed a role for BAG3 in the development of cardiomyopathy in experimental animals leading to the identification of BAG3 mutations in patients with heart failure which may play a part in the onset of disease development and progression.
|
27381181 |
2017 |
|
Congestive heart failure
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Mutations in the BAG3 gene, which encodes a co-chaperone protein, have been associated with heart failure due to both inherited and sporadic dilated cardiomyopathy.
|
28724793 |
2017 |
|
Congestive heart failure
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
To simulate decreased BAG3 protein levels observed in human heart failure, we targeted BAG3 by shRNA (shBAG3) in adult LV myocytes.
|
26796036 |
2016 |
|
Congestive heart failure
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, significant decreases in the level of BAG3 have been found in end-stage failing human heart and in animal models of heart failure including mice with heart failure secondary to trans-aortic banding and in pigs after myocardial infarction.
|
25925243 |
2015 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
BEFREE |
BAG3 plasma concentrations were measured in 39 acutely decompensated HF patients; the primary endpoint was death at 1 year.
|
25753466 |
2015 |
|
Congestive heart failure
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, we also found that the levels of BAG3 protein were significantly reduced in the hearts from unrelated patients with end-stage HF undergoing cardiac transplantation when compared with non-failing controls.
|
24623017 |
2014 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
BEFREE |
Knockdown of bag3 in a zebrafish model recapitulated DCM and heart failure.
|
21353195 |
2011 |
|
Congestive heart failure
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|