PTGES, prostaglandin E synthase, 9536

N. diseases: 150; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE LYA treatment demonstrated consistent improvement in all efficacy measures, suggesting that inhibition of mPGES1 may be an effective treatment for chronic pain associated with OA. 31666405 2019
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE Additional studies are need to clarify the effect of mPGES-1 down-regulation in OA pathology. 29898737 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE To conclude, 11β-HSD1 is a key regulator for the synthesis of mPGES-1 and PGE<sub>2</sub> in the inflammatory synovial cells <i>in vitro</i>, suggesting a potential interference target for osteoarthritis. 28565823 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE Cartilage degeneration was more severe in 12/15-LOX-/- mice compared to WT mice in both models of OA, and this was associated with increased expression of MMP-13, a disintegrin and metalloproteinase with thrombospondin motifs, aggrecanases (ADAMTS5), inducible NO synthases (iNOS), and mPGES-1. 28694081 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE These results indicate that H3K9 demethylation by LSD1 contributes to IL-1β-induced mPGES-1 expression and suggest that this pathway could be a potential target for pharmacological intervention in the treatment of OA and possibly other arthritic conditions. 24886859 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE Modulation of miR-199a* expression also caused significant inhibition of IL-1β-induced upregulation of mPGES1 and prostaglandin E(2) production in OA chondrocytes. 22294637 2012
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE PGE(2) is produced in OA chondrocytes stimulated by IL-1beta by the coordinated induction of cyclooxygenase-2 and microsomal PGE synthase 1 (mPGES-1). 19428335 2009
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE In addition, MF498 was as effective as an nonsteroidal anti-inflammatory drug, diclofenac, or a selective microsomal prostaglandin E synthase-1 inhibitor, MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile], in relieving OA-like pain in guinea pigs. 18287210 2008
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease LHGDN Expression and regulation of microsomal prostaglandin E synthase-1 in human osteoarthritic cartilage and chondrocytes. 15868626 2005
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 Biomarker disease BEFREE Induction of mPGES-1 in the component of articular tissues of patients with rheumatoid arthritis and osteoarthritis has been demonstrated in vitro. 15910650 2005
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis
0.100 AlteredExpression disease BEFREE Finally, the expression of mPGES-1 protein in OA articular cartilage was assessed by immunohistochemistry. 15225371 2004