PTGES, prostaglandin E synthase, 9536

N. diseases: 150; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE Additionally, the representative mPGES-1 tool compounds 9 and 11l revealed moderate in vivo efficacy in the LPS-induced thermal hyperalgesia guinea pig pain model. 28400234 2017
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE However, they were all shown to be considerably less active on rodent mPGES-1, precluding the study of mPGES-1 inhibition in rodent models of inflammation and pain. 23528231 2013
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE In addition, MF498 was as effective as an nonsteroidal anti-inflammatory drug, diclofenac, or a selective microsomal prostaglandin E synthase-1 inhibitor, MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile], in relieving OA-like pain in guinea pigs. 18287210 2008
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE MF63 [2-(6-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)-isophthalonitrile], a selective microsomal prostaglandin E synthase-1 inhibitor, relieves pyresis and pain in preclinical models of inflammation. 18524979 2008
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE MPGES1 has been implicated in a number of human diseases or pathological conditions, such as rheumatoid arthritis, fever, and pain, and is therefore regarded as a primary target for development of novel antiinflammatory drugs. 18682561 2008
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE Studies, mainly from disruption of the mPGES-1 gene in mice, indicate key roles of mPGES-1-generated PGE(2) in female reproduction and in pathological conditions such as inflammation, pain, fever, anorexia, atherosclerosis, stroke, and tumorigenesis. 17878511 2007
CUI: C0030193
Disease: Pain
Pain
0.070 Biomarker phenotype BEFREE Impaired inflammatory and pain responses in mice lacking an inducible prostaglandin E synthase. 12835414 2003