CXCL14, C-X-C motif chemokine ligand 14, 9547

N. diseases: 125; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE <b>Results:</b> CXCL14 protein was expressed in the cytoplasm adjacent to tumors. 28928893 2017
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm
0.010 AlteredExpression disease BEFREE <i>TP53</i>WT endometrioid OC highly expressed CXCL14 compared to <i>TP53</i>m, showing better progression-free survival but no difference in overall survival (OS). 30181917 2018
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary
0.010 AlteredExpression disease BEFREE <i>TP53</i>WT endometrioid OC highly expressed CXCL14 compared to <i>TP53</i>m, showing better progression-free survival but no difference in overall survival (OS). 30181917 2018
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial
0.010 AlteredExpression disease BEFREE <i>TP53</i>WT endometrioid OC highly expressed CXCL14 compared to <i>TP53</i>m, showing better progression-free survival but no difference in overall survival (OS). 30181917 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE Tumour panel blots showed that BRAK was down-regulated in cervical adenocarcinoma and uterine leiomyoma, but was up-regulated in breast invasive ductal carcinoma. 10784614 2000
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 Biomarker group BEFREE Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. 27115465 2016
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 Biomarker group BEFREE Cancer-associated fibroblast-derived CXCL14 enhances tumour growth in mouse models of prostate and breast cancer. 27115465 2016
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms
0.100 AlteredExpression group BEFREE CXCL14 RNA expression was observed in normal and tumor prostate epithelium and focally in stromal cells adjacent to cancer. 15651028 2005
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm
0.100 AlteredExpression group BEFREE CXCL14 RNA expression was observed in normal and tumor prostate epithelium and focally in stromal cells adjacent to cancer. 15651028 2005
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma
0.030 AlteredExpression disease BEFREE CXCL14 mRNA upregulation is a common feature in prostate cancer. 15651028 2005
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.020 AlteredExpression disease BEFREE CXCL14 mRNA upregulation is a common feature in prostate cancer. 15651028 2005
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.010 Biomarker group BEFREE CXCL14 is an autocrine growth factor for fibroblasts and acts as a multi-modal stimulator of prostate tumor growth. 19218429 2009
Squamous cell carcinoma of the head and neck
0.090 AlteredExpression disease BEFREE BRAK/CXCL14 (breast- and kidney-expressed chemokine/CXC chemokine ligand 14) is a chemokine that is expressed in many normal cells and tissues but is absent from or expressed at very low levels in transformed cells and cancerous tissues, including HNSCC (head and neck squamous cell carcinoma). 20067447 2010
CUI: C1368683
Disease: Epithelioma
Epithelioma
0.010 AlteredExpression disease BEFREE CXCL14 expression is constitutive in normal tissues, but absent in wide range of epithelial tumors. 21556757 2012
Secondary malignant neoplasm of lymph node
0.010 AlteredExpression disease BEFREE CXCL14 protein level is positively correlated to the overall survival of all patients as well as the patients with lymph node metastasis, and it has a negative correlation with the lymph node metastasis. 22910931 2012
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.070 AlteredExpression disease BEFREE CXCL14 mRNA expression is lower in breast cancer cell lines, and MDA-MB-231HM express the lowest levels of CXCL14 mRNA. 22910931 2012
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.070 AlteredExpression disease BEFREE CXCL14 mRNA expression is lower in breast cancer cell lines, and MDA-MB-231HM express the lowest levels of CXCL14 mRNA. 22910931 2012
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis
0.030 Biomarker phenotype BEFREE CXCL14, a recently described epithelial cytokine, plays putative multiple roles in inflammation and carcinogenesis. 23597004 2013
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma
0.030 PosttranslationalModification disease BEFREE CXCL14 was methylated in 79.4% (85/107) of primary human colorectal cancer. 24099668 2013
Malignant neoplasm of colon and/or rectum
0.010 PosttranslationalModification disease BEFREE CXCL14 was methylated in 79.4% (85/107) of primary human colorectal cancer. 24099668 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 AlteredExpression group BEFREE CXCL14 is a member of the CXCL chemokine family and exhibits various expression patterns in different types of tumor, even those tumors that occur in the same type of tissue. 24938992 2014
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm
0.020 AlteredExpression group BEFREE CXCL14, CXCR7 expression and CXCR4 splice variant ratio associate with survival and metastases in Ewing sarcoma patients. 26428435 2015
CUI: C0206687
Disease: Carcinoma, Endometrioid
Carcinoma, Endometrioid
0.010 Biomarker disease BEFREE CXCL14-CXCR4 and CXCL12-CXCR4 Axes May Play Important Roles in the Unique Invasion Process of Endometrioid Carcinoma With MELF-Pattern Myoinvasion. 28277316 2017
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection
0.010 Biomarker disease BEFREE CXCL14 did not activate CXCR4-expressing cells (<i>i.e.,</i> failed to trigger chemotaxis and Ca<sup>2+</sup> mobilization, as well as signaling <i>via</i> ERK1/2 and the small GTPase Rac1); however, CXCL14 bound to CXCR4 with high affinity, induced redistribution of cell-surface CXCR4, and enhanced HIV-1 infection by >3-fold. 28360196 2017
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.100 Biomarker group BEFREE CXCL14 is a primordial chemokine that plays multiple roles in tumor suppression, autoimmune arthritis, and obesity-associated insulin resistance. 28928016 2017