|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In Kampala, Uganda, there are three sub-lineages of M. tuberculosis lineage 3 that cause disease of comparable severity with CAS-Dehli as the most prevalent.
|
31498808 |
2019 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
We found that Cas1 increased the sensitivity to multiple anti-tuberculosis drugs by reducing the persistence during drug treatment.
|
31061828 |
2019 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Available associated information on gender (n = 18,944), age (n = 16,968), drug resistance (n = 19,606), and HIV serology (n = 2673), allowed to draw some important conclusions on TB geo-epidemiology; e.g. a positive correlation exists between certain Mycobacterium tuberculosis lineages (such as CAS and Beijing) and drug resistance (p-value<.001), while other lineages (such as LAM, X, and BOV) are more frequently associated with HIV-positive serology (p-value<.001).
|
30593925 |
2019 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The objective of this study was to determine in vitro, the susceptibility patterns of M. tuberculosis Uganda family compared with Beijing and Delhi/CAS, other M. tuberculosis sub-lineages that also circulate in Uganda but are not as prevalent.
|
27097724 |
2016 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most frequent superfamily of M tuberculosis in clinical isolates was Delhi/CAS (142, 30.3%) followed by NEW-1 (127, 27%).
|
25340935 |
2015 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The involvement of Beijing and CAS1-Delhi clades in paediatric TB patients suggests that these two lineages play a major role in ongoing active transmission.
|
25216830 |
2014 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, high congruence between the MIRU-VNTR-based and spoligotyping-based strain groupings suggests that CAS, EAI and Beijing are the predominant strain lineages in the Mumbai TB patient population.
|
22321730 |
2012 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The most frequent M. tuberculosis lineage was Lineage 3 (CAS/Delhi) with 106 isolates (40.6%), followed by Lineage 2 (East-Asian lineage, includes Beijing genotype) with 84 isolates (32.2%), Lineage 4 (Euro-American lineage) with 41 (15.7%) isolates, and Lineage 1 (Indo-Oceanic lineage) with 30 isolates (11.5%).
|
23300635 |
2012 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Central Asian Strain 1 (CAS1) is the predominant Mycobacterium tuberculosis genotype in Pakistan.
|
21389589 |
2011 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The predominant genotypes of Mycobacterium tuberculosis are reported to be the Central Asian strain 1 (CAS1) and Beijing families.Mycobacteriumtuberculosis down-regulates host pro-inflammatory cytokines, which are essential for protection against infection.
|
19375139 |
2009 |
|
Tuberculosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Also TbD1 analysis (M. tuberculosis specific deletion 1) confirmed that CAS1 was of "modern" origin while EAI isolates belonged to "ancestral" strain types.Prevalence of CAS1 clade was significantly higher in Punjab (P < 0.01, Pearsons Chi-square test) as compared with Sindh, North West Frontier Province and Balochistan provinces.
|
19108722 |
2008 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Two STs; ST26 (CAS_Delhi) and ST1 (Beijing) represented 36.1% of the total M. tuberculosis population in eastern Uttar Pradesh, North India.
|
18372222 |
2008 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The fact that the predominant strain, CAS1, is not associated with drug resistance is encouraging and suggests that an effective tuberculosis control program should be able to limit the high incidence of disease in this region.
|
16672404 |
2006 |
|
Tuberculosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The observed distribution of genotypes shows that principal genetic group 1 strains (EAI, Beijing, CAS, Afri, "Manu") is high (35.4%) suggesting an ancient evolutionary history of tuberculosis in Madagascar, in relation to the origin of peopling and the demographic history.
|
16168940 |
2005 |