|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD in the Han Chinese population.
|
25789810 |
2015 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Several circadian genes have been found to be associated with bipolar disorders: at least three studies have reported positive associations for each of CLOCK, NPAS2, ARNTL1, NR1D1, PER3, RORB and CSNK1epsilon.
|
24389266 |
2014 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
|
22538398 |
2012 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The findings that have gained support indicate that genetic variants of RORA (rs2028122) and CRY1 (rs2287161) associate with depressive disorder, those of RORB (rs7022435, rs3750420, rs1157358, rs3903529) and NR1D1 (rs2314339) with bipolar disorder, and those of NPAS2 (rs11541353) and CRY2 (rs10838524) with seasonal affective disorder or winter depression.
|
22538398 |
2012 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Such connections to circadian genes such as CLOCK, ARNTL1, NPAS2, PER3 and NR1D1 have been repeatedly demonstrated for bipolar disorders, and to a lesser extent for recurrent depressive disorders and seasonal affective disorders.
|
21835597 |
2011 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
Using lymphoblastoid cell lines from patients with BD, we found that both the NR1D1 and GSK3β variants are associated with functional differences in gene expression.
|
21781277 |
2011 |
|
Bipolar Disorder
|
0.330 |
Biomarker
|
disease |
PSYGENET |
We examined 209 single-nucleotide polymorphisms (SNPs) covering 19 circadian genes (ADCYAP1, ARNTL, ARNTL2, BHLHB2, BHLHB3, CLOCK, CRY1, CRY2, CSNK1E, DBP, NPAS2, NR1D1, PER1, PER2, PER3, RORA, TIMELESS, VIP, and VIPR2) in a sample of 534 MD patients (335 with unipolar major mood depression (MDD) and 199 with bipolar disorder (BD)) and 440 community-based screened controls.
|
20072116 |
2010 |
|
Bipolar Disorder
|
0.330 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to investigate the association between REV-ERBalpha gene (NR1D1) single nucleotide polymorphisms (SNPs) and bipolar disorder (BP) in a case-control sample of Sardinian ancestry and evaluate its effect on age at onset (AAO) of BP.
|
19267705 |
2009 |