|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
Our results point to the use of NCoR and TRβ as potential biomarkers for diagnosis or prognosis in breast cancer and suggest that further studies of these molecules as potential targets for anti-lymphangiogenic therapy are warranted.
|
27806339 |
2016 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
Our results point to the use of NCoR and TRβ as potential biomarkers for diagnosis or prognosis in breast cancer and suggest that further studies of these molecules as potential targets for anti-lymphangiogenic therapy are warranted.
|
27806339 |
2016 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
CTD_human |
The objective of the study is to investigate the expression of NCOR1 at the protein level and pursue its predictive value for breast cancer endocrine therapy.
|
19781322 |
2009 |
|
Malignant neoplasm of breast
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Thus, we set out to identify novel single nucleotide polymorphisms (SNPs) within SRC-1 (NCoA1), SRC-3 (NCoA3, AIB1), NCoR (NCoR1), and SMRT (NCoR2), and test the most promising SNPs for associations with breast cancer risk.
|
20003447 |
2009 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
CTD_human |
In the present study, the level of expression of NCOR1 protein has been assessed by immunohistochemistry in 104 cases of invasive carcinoma of the breast.
|
19781322 |
2009 |
|
Breast Carcinoma
|
0.550 |
GeneticVariation
|
disease |
BEFREE |
Thus, we set out to identify novel single nucleotide polymorphisms (SNPs) within SRC-1 (NCoA1), SRC-3 (NCoA3, AIB1), NCoR (NCoR1), and SMRT (NCoR2), and test the most promising SNPs for associations with breast cancer risk.
|
20003447 |
2009 |
|
Malignant neoplasm of breast
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer.
|
16019133 |
2006 |
|
Malignant neoplasm of breast
|
0.550 |
Biomarker
|
disease |
BEFREE |
Both primary tissue models and cancer cell lines displayed a spectrum of suppressed responsiveness towards 1alpha, 25 hydroxy vitamin D3 (1alpha25(OH)2D3) which correlated with elevated co-repressor content: specifically, elevated silencing mediator of retinoid and thyroid hormone receptors/nuclear co-repressor 2 (NCoR2/SMRT) in prostate cancer cell lines and primary tumour cultures, and elevated nuclear receptor co-repressor 1 (NCoR1) in breast cancer cell lines.
|
16886664 |
2006 |
|
Malignant neoplasm of breast
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Increased NCoR1 mRNA is a novel molecular lesion in breast cancer cells, which acts to suppress responsiveness of VDR target genes, resulting in 1alpha,25(OH)(2)D(3) resistance and seems to be particularly associated with estrogen receptor negativity.
|
16609009 |
2006 |
|
Breast Carcinoma
|
0.550 |
Biomarker
|
disease |
BEFREE |
Both primary tissue models and cancer cell lines displayed a spectrum of suppressed responsiveness towards 1alpha, 25 hydroxy vitamin D3 (1alpha25(OH)2D3) which correlated with elevated co-repressor content: specifically, elevated silencing mediator of retinoid and thyroid hormone receptors/nuclear co-repressor 2 (NCoR2/SMRT) in prostate cancer cell lines and primary tumour cultures, and elevated nuclear receptor co-repressor 1 (NCoR1) in breast cancer cell lines.
|
16886664 |
2006 |
|
Breast Carcinoma
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Increased NCoR1 mRNA is a novel molecular lesion in breast cancer cells, which acts to suppress responsiveness of VDR target genes, resulting in 1alpha,25(OH)(2)D(3) resistance and seems to be particularly associated with estrogen receptor negativity.
|
16609009 |
2006 |
|
Breast Carcinoma
|
0.550 |
AlteredExpression
|
disease |
BEFREE |
Univariate and multivariate prognostic analysis demonstrated that NCOR1 mRNA is an independent prognostic factor for breast cancer.
|
16019133 |
2006 |
|
Malignant neoplasm of breast
|
0.550 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Breast Carcinoma
|
0.550 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Mammary Neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
Evaluation of transcriptionally regulated genes identifies NCOR1 in hormone receptor negative breast tumors and lung adenocarcinomas as a potential tumor suppressor gene.
|
30485330 |
2018 |
|
Mammary Neoplasms
|
0.330 |
Biomarker
|
group |
BEFREE |
The clinical significance of these results is stressed by the finding that NCoR and TRβ transcripts correlate negatively with those of the lymphangiogenic genes and the lymphatic vessel marker LYVE-1 in human breast tumors.
|
27806339 |
2016 |
|
Mammary Neoplasms
|
0.330 |
Biomarker
|
group |
CTD_human |
Nuclear corepressor 1 expression predicts response to first-line endocrine therapy for breast cancer patients on relapse.
|
19781322 |
2009 |
|
Mammary Neoplasms
|
0.330 |
AlteredExpression
|
group |
LHGDN |
Cell cycle progression stimulated by tamoxifen-bound estrogen receptor-alpha and promoter-specific effects in breast cancer cells deficient in N-CoR and SMRT.
|
15802375 |
2005 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
CTD_human |
The long tail of oncogenic drivers in prostate cancer.
|
29610475 |
2018 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
Prostate cancer metastases show significant decrease in NCOR1 transcriptional output.
|
26968201 |
2016 |
|
Malignant neoplasm of prostate
|
0.320 |
Biomarker
|
disease |
BEFREE |
Interrogation of these relationships in prostate cancer samples using principal component and partial correlation analyses established significant interdependent relationships between NCOR1-PPARalpha/gamma and representative target genes, independently of androgen receptor expression.
|
20466759 |
2010 |
|
Prostatic Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
The long tail of oncogenic drivers in prostate cancer.
|
29610475 |
2018 |
|
Hyperbilirubinemia, Neonatal
|
0.300 |
Biomarker
|
disease |
CTD_human |
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
|
28167773 |
2017 |
|
Direct Hyperbilirubinemia, Neonatal
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
|
28167773 |
2017 |
|
Indirect Hyperbilirubinemia, Neonatal
|
0.300 |
Biomarker
|
disease |
CTD_human |
Intestinal NCoR1, a regulator of epithelial cell maturation, controls neonatal hyperbilirubinemia.
|
28167773 |
2017 |