ISG15, ISG15 ubiquitin like modifier, 9636

N. diseases: 148; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Understandably, an increased IFN-β level facilitated phosphorylation of STAT1 to induce expression of innate antiviral genes Mx1 and ISG15, suggesting that TLR4 overexpressing macrophages were equipped better against viral infection. 30522781 2019
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE These findings are integrated with a discussion of the recent identification of ISG15-deficient individuals and a cellular receptor for ISG15 that provides new insights into how ISG15 shapes the host response to viral infection. 29769653 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Interferon-stimulated gene 15 (ISG15) plays an important antiviral role during viral infection. 30428561 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE ISG15, an IFN-stimulated ubiquitin-like protein, is highly increased during virus infection and participates in the IFN-mediated antiviral immune response. 30201339 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 AlteredExpression group BEFREE ISG15 expression and protein ISGylation modulate viral infection; however, the viral mechanisms regulating the function of ISG15 and ISGylation are not well understood. 29743376 2018
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE In vitro and in vivo evidences suggest that free ISG15 play different roles in several cellular processes, from cancer and defense against viral infections to activation of immune cells such as lymphocytes, monocytes, and NK cells. 28467275 2017
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE We previously published a study describing humans with inherited ISG15 deficiency but without unusually severe viral diseases. 25307056 2015
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE ISG15 is counteracted by vaccinia virus E3 protein and controls the proinflammatory response against viral infection. 24257616 2014
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE Moreover, peritoneal macrophages from mice lacking ISG15 are neither able to phagocyte infected cells nor to block viral infection in co-culture experiments with VACV-infected murine embryonic fibroblast (MEFs). 24137104 2013
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The lack of intracellular ISG15 production and protein ISGylation was not associated with cellular susceptibility to any viruses that we tested, consistent with the lack of viral diseases in these patients. 22859821 2012
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE These subtle differences in Ub/ISG15 binding allowed the design of vOTU variants specific for either Ub or ISG15, which will be useful tools to understand the relative contribution of ubiquitination vs. ISGylation in viral infection. 21266548 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 Biomarker group BEFREE The ISG15/USP18 pathway modulates cellular functions and is important for the host innate immune response to chronic viral infections such as Hepatitis C Virus (HCV). 21704181 2011
CUI: C0042769
Disease: Virus Diseases
Virus Diseases
0.100 GeneticVariation group BEFREE We assessed the role of ISG15-UbE1L interactions in control of virus infection by constructing double subgenomic Sindbis viruses that expressed the mISG15 R151A mutant. 19073728 2009