|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation.
|
25307056 |
2015 |
|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
ISG15: leading a double life as a secreted molecule.
|
23579383 |
2013 |
|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
|
22859821 |
2012 |
|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
|
22859821 |
2012 |
|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.
|
22859821 |
2012 |
|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
IMMUNODEFICIENCY 38 WITH BASAL GANGLIA CALCIFICATION
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Host genetic polymorphisms, such as inosine triphosphatase (ITPA), interferon, lambda 3 (IFNL3), Q5 interferon, lambda 4 (IFNL4), toll-like receptors (TLRs) and interferon-stimulated gene 15 (ISG-15), were identified as key genes for treatment prediction and HCC evolution.
|
30614131 |
2019 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of ISG15 increased the sensitivity of HCC cells to norcantharidin, and norcantharidin treatment reversed the tumor-promoting effects of ISG15 overexpression exerted in HCC cells.
|
31611931 |
2019 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
miR-370 regulates ISG15 expression and influences IFN-α sensitivity in hepatocellular carcinoma cells.
|
29758929 |
2018 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
HZ-6d targeted HERC5 to regulate p53 ISGylation in human hepatocellular carcinoma.
|
28919514 |
2017 |
|
Liver carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
ISG15 promotes the proliferation and migration of hepatocarcinoma cells through maintaining Survivin protein stabilization via sequestering XIAP from interacting with Survivin.
|
25238261 |
2014 |
|
Liver carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that ISG15 overexpression could be developed into a powerful gene-therapeutic tool for treating IFN-α-resistant HCC.
|
24024201 |
2013 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
The first 145 amino acids of the NS1 protein are required for inhibition of ISG15-mediated ubiquitination, and our analysis showed that Influenza B viruses circulating in Singapore with DP<sub>92-93</sub> expressed truncated NS1 proteins and may differ in their capacity to inhibit ISG15 activity.
|
28348873 |
2016 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Additionally, significant DEGs in module 2, including radical S‑adenosyl methionine domain containing 2 (RSAD2), 2'‑5'‑oligoadenylate synthetase 2 (OAS2), myxovirus (influenza virus) resistance 1 (MX1) and ISG15 ubiquitin‑like modifier (ISG15), were predominantly associated with immune function pathways.
|
27356888 |
2016 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
CTD_human |
A host transcriptional signature for presymptomatic detection of infection in humans exposed to influenza H1N1 or H3N2.
|
23326326 |
2013 |
|
Influenza
|
0.330 |
Biomarker
|
disease |
BEFREE |
Species specificity of the NS1 protein of influenza B virus: NS1 binds only human and non-human primate ubiquitin-like ISG15 proteins.
|
20093371 |
2010 |
|
Involutional Depression
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Major Depressive Disorder
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Involutional paraphrenia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Psychosis, Involutional
|
0.300 |
Biomarker
|
disease |
CTD_human |
Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder.
|
29175309 |
2018 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Differential gene expression pattern of diabetic rat retinas after intravitreal injection of erythropoietin.
|
20973890 |
2011 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thereby, the current study displayed a novel mechanism by which TRIM29 modulates ISG15 stability via CAPN3-mediated processing, and subsequently extracellular ISG15 maintains the cancer stem cell-like features of PDAC via autocrine mode of action.
|
31501523 |
2020 |
|
Primary malignant neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
Thereby, the current study displayed a novel mechanism by which TRIM29 modulates ISG15 stability via CAPN3-mediated processing, and subsequently extracellular ISG15 maintains the cancer stem cell-like features of PDAC via autocrine mode of action.
|
31501523 |
2020 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, expression of ISG15 and ISG15 conjugation machinery in cancer cells is directly up-regulated by TNF-α via p38 MAPK and JNK pathways through the activation of C/EBPβ binding element in the ISG15 promoter.
|
31428903 |
2019 |