CD59, CD59 molecule (CD59 blood group), 966

N. diseases: 262; N. variants: 7
Disease: Neuromyelitis Optica ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 Biomarker disease BEFREE Complement regulator CD59 prevents peripheral organ injury in rats made seropositive for neuromyelitis optica immunoglobulin G. 28750658 2017
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 Biomarker disease BEFREE Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. 28212662 2017
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 ModifyingMutation disease RGD Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. 28212662 2017
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 AlteredExpression disease BEFREE Our findings suggest that low CD59 expression in astrocytes may contribute to central nervous system-restricted lesions in neuromyelitis optica spectrum disorder. 28476558 2017
CUI: C0027873
Disease: Neuromyelitis Optica
Neuromyelitis Optica 		0.240 Biomarker disease BEFREE Intrathecal injection (at L5-L6) of small amounts of NMO-IgG and human complement in CD59-deficient mice produced robust, longitudinally extensive white matter lesions in lumbar spinal cord. 24698947 2014