CD59, CD59 molecule (CD59 blood group), 966

N. diseases: 262; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 CausalMutation disease CLINVAR
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 Biomarker disease CTD_human
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GeneticVariation disease CLINVAR
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.500 Biomarker disease HPO
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic 		0.120 Biomarker disease HPO
CUI: C0152025
Disease: Polyneuropathy
Polyneuropathy 		0.120 Biomarker disease HPO
CUI: C0234146
Disease: Absent reflex
Absent reflex 		0.100 Biomarker phenotype HPO
CUI: C0522224
Disease: Paralysed
Paralysed 		0.100 Biomarker phenotype HPO
CUI: C0541794
Disease: Skeletal muscle atrophy
Skeletal muscle atrophy 		0.100 Biomarker phenotype HPO
CUI: C0587246
Disease: Muscle weakness of limb
Muscle weakness of limb 		0.100 Biomarker phenotype HPO
CUI: C1806780
Disease: Increased CSF protein
Increased CSF protein 		0.100 Biomarker phenotype HPO
CUI: C1858120
Disease: Generalized hypotonia
Generalized hypotonia 		0.100 Biomarker phenotype HPO
CUI: C0751362
Disease: Narcolepsy-Cataplexy Syndrome
Narcolepsy-Cataplexy Syndrome 		0.010 Biomarker disease BEFREE 130 patients with narcolepsy-cataplexy (mean ± SD age 20 ± 10 yrs, 69% male) and 117 controls (22 ± 6.9 yrs, 62% male) were recruited and tested for human leukocyte antigen (HLA)-DQB1*0602 status, hyperoxia hypercapnic (change in minute ventilation (δV'(E))/carbon dioxide tension (δP(CO(2))) L·min(-1)·mmHg(-1)) and hypoxic (δV'(E) /change in arterial oxygen saturation measured by probe oximetry (δS(p,O(2))) L·min(-1) per %S(p,O(2))) responsiveness, and by spirometry. 20110394 2010
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.500 GeneticVariation disease BEFREE Paroxysmal nocturnal hemoglobinuria (PNH) is a hematopoietic disorder caused by PIGA mutations that lead to a loss of all glycosylphospatidylinositol (GPI)-anchored proteins including, CD55 and CD59. 15160958 2004
CUI: C0151636
Disease: Premature ventricular contractions
Premature ventricular contractions 		0.010 Biomarker phenotype BEFREE Premature ventricular complexes appeared later and at higher heart rate during verapamil than at baseline (119+/-21 vs. 127+/-27 min-1, P<0.05). 15720454 2005
CUI: C1504514
Disease: Infection by human herpesvirus 7
Infection by human herpesvirus 7 		0.010 AlteredExpression disease BEFREE Human herpesvirus 7 infection increases the expression levels of CD46 and CD59 in target cells. 17412968 2007
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.500 Biomarker disease BEFREE Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by absence of CD55 and CD59 from the surface of affected cells. 18158579 2008
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.010 Biomarker phenotype BEFREE Endotoxemia induced systemic IR as demonstrated by a 35% decrease in S(i) (3.17 +/- 1.66 to 2.06 +/- 0.73 x 10(-4) [microU * ml(-1) * min(-1)], P < 0.005), while there was no effect on pancreatic beta-cell function. 19794059 2010
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.020 Biomarker disease BEFREE Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cells from complement attack. 21665888 2011
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases 		0.080 Biomarker group BEFREE Chronic kidney disease (CKD) was diagnosed in individuals with proteinuria and/or decreased eGFR ≤60 ml min(-1) per 1.73 m(2). 21832999 2011
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GermlineCausalMutation disease ORPHANET CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GeneticVariation disease BEFREE CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 GeneticVariation disease UNIPROT CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C2676767
Disease: CD59 Deficiency
CD59 Deficiency 		0.760 Biomarker disease GENOMICS_ENGLAND CD59 deficiency is a common finding in RBCs and WBCs in patients with chronic hemolysis suffering from paroxysmal nocturnal hemoglobinuria in which the acquired mutation in the PIGA gene leads to membrane loss of glycosylphosphatidylinositol-anchored membrane proteins, including CD59. 23149847 2013
CUI: C0024790
Disease: Paroxysmal nocturnal hemoglobinuria
Paroxysmal nocturnal hemoglobinuria 		0.500 GeneticVariation disease BEFREE PNH is due to a somatic, acquired mutation in the X-linked phosphatidylinositol glycan class A (PIG-A) gene, which impairs the membrane expression on affected blood cells of a number of proteins, including the complement regulators CD55 and CD59. 23402025 2013