CD59, CD59 molecule (CD59 blood group), 966

N. diseases: 262; N. variants: 7
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.120 Biomarker disease BEFREE CD59 is the main inhibitor of the membrane attack complex, and its deficiency leads to complement attack on erythrocytes and severe haemolytic anaemia, which is now amenable to treatment with an inhibitor of C5 cleavage. 28345259 2017
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.120 Biomarker disease BEFREE Although the pathogenesis of hemolytic anemia in PNH is related to the absence of CD55 and CD59 molecules on the membrane of red cells, the mechanism responsible for the increased incidence of thrombotic events in PNH is not clear. 8885138 1996
CUI: C0002878
Disease: Anemia, Hemolytic
Anemia, Hemolytic
0.120 Biomarker disease HPO