Bronchopulmonary Dysplasia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The following genotypes were associated with respiratory severity outcomes: BPD-fetal Importin 13 gene (IPO13; rs4448553; odds ratio [OR], 0.01; 95% confidence interval [CI], 0.00-0.92); surfactant use-maternal IPO13 (rs2428953 and 2486014; OR, 13.8; 95% CI, 1.80-105.5; and OR, 35.5; 95% CI, 1.71-736.6, respectively).
|
23295978 |
2013 |
Cataract
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Mutation of IPO13 causes recessive ocular coloboma, microphthalmia, and cataract.
|
29700284 |
2018 |
Childhood asthma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Importin-13 genetic variation is associated with improved airway responsiveness in childhood asthma.
|
19619331 |
2009 |
Asthma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We hypothesize that common IPO13 genetic variation influences the anti-inflammatory effects of inhaled corticosteroids for the treatment of asthma, as measured by change in methacholine airway hyperresponsiveness (AHR-PC20).
|
19619331 |
2009 |
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thereby, ZEB1 suppresses the expression of cell polarity factors, in particular of Lgl2, which we found reduced in colorectal and breast cancers.
|
18199550 |
2008 |
Congenital ocular coloboma (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Morpholino-oligonucleotide-induced knockdown of ipo13 in zebrafish caused dose-dependent microphthalmia and coloboma, which is highly similar to the ocular phenotypes in the patient.
|
29700284 |
2018 |
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that Lgl2 loss occurs at an early stage of gastric carcinogenesis and contributes to GC progression.
|
24337435 |
2014 |
Microphthalmos
|
0.010 |
Biomarker
|
disease |
BEFREE |
Morpholino-oligonucleotide-induced knockdown of ipo13 in zebrafish caused dose-dependent microphthalmia and coloboma, which is highly similar to the ocular phenotypes in the patient.
|
29700284 |
2018 |
Respiratory syncytial virus (RSV) infection in conditions classified elsewhere and of unspecified site
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our findings provide a mechanism for the ineffectiveness of glucocorticoids in RSV-related disease and highlight the potential to target the IPO13-GR axis as a treatment for multiple glucocorticoid-related diseases.
|
28968829 |
2017 |
Endometrial Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma, which could be involved in the pathogenesis of endometriosis and endometrial carcinoma; IPO13 can serve as an endometrial progenitor/stem cell marker.
|
22648251 |
2012 |
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results suggest that Lgl2 loss occurs at an early stage of gastric carcinogenesis and contributes to GC progression.
|
24337435 |
2014 |
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our results suggest that Lgl2 loss occurs at an early stage of gastric carcinogenesis and contributes to GC progression.
|
24337435 |
2014 |
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The 5'-CpG islands of both miR-200 loci were found unmethylated and coupled to the expression of the corresponding miRNAs in human cancer cell lines with epithelial features, such as low levels of ZEB1/ZEB2 and high expression of E-cadherin, CRB3 and LGL2, while CpG island hypermethylation-associated silencing was observed in transformed cells with mesenchymal characteristics.
|
21874049 |
2012 |
Endometriosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These results demonstrate an increased expression of IPO13 in endometriosis and endometrial carcinoma, which could be involved in the pathogenesis of endometriosis and endometrial carcinoma; IPO13 can serve as an endometrial progenitor/stem cell marker.
|
22648251 |
2012 |
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We further show that retention of Lgl2 expression is critical for the epithelial phenotype and that its loss might be involved in metastasis.
|
18199550 |
2008 |
Pterygium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IPO13 activity was significantly increased in the basal layer of the epithelium of the pterygium.
|
23559854 |
2013 |
Uterine Polyp
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of IPO13, c-kit, telomerase, caspase3, and bax were decreased; however, the expression of bcl-2 was increased in the EP tissue compared to the normal endometrial tissue.
|
21804459 |
2011 |
Gastric dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
During gastric carcinogenesis, membrane expression of Lgl2 was progressively lost in 4 % of normal mucosa, 75 % of intestinal metaplasia, 58 % of gastric dysplasia, 69 % of intestinal type GC, and 96 % of diffuse type GC.
|
24337435 |
2014 |
Intestinal metaplasia
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
During gastric carcinogenesis, membrane expression of Lgl2 was progressively lost in 4 % of normal mucosa, 75 % of intestinal metaplasia, 58 % of gastric dysplasia, 69 % of intestinal type GC, and 96 % of diffuse type GC.
|
24337435 |
2014 |
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The 5'-CpG islands of both miR-200 loci were found unmethylated and coupled to the expression of the corresponding miRNAs in human cancer cell lines with epithelial features, such as low levels of ZEB1/ZEB2 and high expression of E-cadherin, CRB3 and LGL2, while CpG island hypermethylation-associated silencing was observed in transformed cells with mesenchymal characteristics.
|
21874049 |
2012 |
Pterygium Of Conjunctiva And Cornea
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IPO13 activity was significantly increased in the basal layer of the epithelium of the pterygium.
|
23559854 |
2013 |
Pterygium of eye
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
IPO13 activity was significantly increased in the basal layer of the epithelium of the pterygium.
|
23559854 |
2013 |