Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease BEFREE A number of mQTL SNPs were associated with reproductive traits and diseases, including one mQTL located in a known risk region for endometriosis (near GREB1). 30871624 2019
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease BEFREE However, although rs11674184 of GREB1 constitutes one of the most consistently associated SNPs with endometriosis in European ancestry populations, it was not found to be associated with endometriosis in this study. 31115525 2019
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease GWASCAT Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism. 28537267 2017
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 AlteredExpression disease BEFREE The differential expression of GREB1 has also been reported by others in association with endometriosis disease phenotype. 25788566 2015
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease BEFREE Notably, three coding variants in GREB1 (near rs13394619) and CDKN2B-AS1 (near rs1537377) also showed nominally significant associations with endometriosis. 26337243 2015
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease BEFREE In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871). 23104006 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 Biomarker disease CTD_human In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871). 23104006 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease GWASDB In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871). 23104006 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 Biomarker disease BEFREE To analyze the expression of estrogen receptors α and β as well as their target genes implicated in proliferation, c-myc, cyclin D1, and GREB1, in the endometrium of women with or without endometriosis. 22884659 2012
CUI: C0014175
Disease: Endometriosis
Endometriosis
0.460 GeneticVariation disease GWASCAT In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871). 23104006 2012
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE Additionally, GREB1 responds to androgen in prostate cancer cells, and can stimulate the proliferation of breast, ovarian, and prostate cancer cells. 30154312 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE GREB1 knockdown prevents hormone-driven proliferation of several breast and prostate cancer cell lines and prolongs survival of mice engrafted with ovarian cancer cells, but its mechanism of action remains unclear. 29973689 2018
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE Although its exact function in the cascade of hormone action remains unclear, the ability of GREB1 to modulate tumor progression in models of breast, ovarian and prostate cancer renders this gene an excellent candidate for further consideration as a potential therapeutic target. 24998469 2014
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 AlteredExpression disease BEFREE Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis. 19945309 2012
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease CTD_human GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation. 16496412 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate
0.350 Biomarker disease BEFREE GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation. 16496412 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.310 Biomarker group CTD_human GREB1 is a novel androgen-regulated gene required for prostate cancer growth. 16496412 2006
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms
0.310 AlteredExpression group LHGDN GREB1 is a novel androgen-regulated gene required for prostate cancer growth. 16496412 2006
CUI: C0269102
Disease: Endometrioma
Endometrioma
0.300 Biomarker disease CTD_human Genome-wide association meta-analysis identifies new endometriosis risk loci. 23104006 2012
CUI: C0042133
Disease: Uterine Fibroids
Uterine Fibroids
0.100 GeneticVariation group GWASCAT Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. 31649266 2019
CUI: C1314691
Disease: Age at menarche
Age at menarche
0.100 GeneticVariation phenotype GWASCAT Leveraging Polygenic Functional Enrichment to Improve GWAS Power. 30595370 2019
CUI: C2242776
Disease: Plexiform leiomyoma
Plexiform leiomyoma
0.100 GeneticVariation disease GWASCAT Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. 31649266 2019
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE GREB1 isoforms regulate proliferation independent of ERα co-regulator activities in breast cancer. 29695586 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 Biomarker disease BEFREE GREB1 also ensured proper cellular reactions to different ligands by recruiting distinct sets of ERα cofactors to <i>cis</i>-regulatory elements, which explains the contradictory biological effects of GREB1 on breast cancer cell growth in response to estrogen or antiestrogen. 29212856 2018
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.100 GeneticVariation disease BEFREE Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1). 30194396 2018