Endometriosis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
A number of mQTL SNPs were associated with reproductive traits and diseases, including one mQTL located in a known risk region for endometriosis (near GREB1).
|
30871624 |
2019 |
Endometriosis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
However, although rs11674184 of GREB1 constitutes one of the most consistently associated SNPs with endometriosis in European ancestry populations, it was not found to be associated with endometriosis in this study.
|
31115525 |
2019 |
Endometriosis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism.
|
28537267 |
2017 |
Endometriosis
|
0.460 |
AlteredExpression
|
disease |
BEFREE |
The differential expression of GREB1 has also been reported by others in association with endometriosis disease phenotype.
|
25788566 |
2015 |
Endometriosis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
Notably, three coding variants in GREB1 (near rs13394619) and CDKN2B-AS1 (near rs1537377) also showed nominally significant associations with endometriosis.
|
26337243 |
2015 |
Endometriosis
|
0.460 |
GeneticVariation
|
disease |
BEFREE |
In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).
|
23104006 |
2012 |
Endometriosis
|
0.460 |
Biomarker
|
disease |
CTD_human |
In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).
|
23104006 |
2012 |
Endometriosis
|
0.460 |
GeneticVariation
|
disease |
GWASDB |
In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).
|
23104006 |
2012 |
Endometriosis
|
0.460 |
Biomarker
|
disease |
BEFREE |
To analyze the expression of estrogen receptors α and β as well as their target genes implicated in proliferation, c-myc, cyclin D1, and GREB1, in the endometrium of women with or without endometriosis.
|
22884659 |
2012 |
Endometriosis
|
0.460 |
GeneticVariation
|
disease |
GWASCAT |
In addition, we establish an association of rs13394619 in GREB1 at 2p25.1 with endometriosis and identify a newly associated locus at 12q22 near VEZT (rs10859871).
|
23104006 |
2012 |
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
Additionally, GREB1 responds to androgen in prostate cancer cells, and can stimulate the proliferation of breast, ovarian, and prostate cancer cells.
|
30154312 |
2018 |
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
GREB1 knockdown prevents hormone-driven proliferation of several breast and prostate cancer cell lines and prolongs survival of mice engrafted with ovarian cancer cells, but its mechanism of action remains unclear.
|
29973689 |
2018 |
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
Although its exact function in the cascade of hormone action remains unclear, the ability of GREB1 to modulate tumor progression in models of breast, ovarian and prostate cancer renders this gene an excellent candidate for further consideration as a potential therapeutic target.
|
24998469 |
2014 |
Malignant neoplasm of prostate
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Tissue expression of GREB1 is associated with organ-confined prostate cancer and may constitute a gene associated with a favorable prognosis.
|
19945309 |
2012 |
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
CTD_human |
GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation.
|
16496412 |
2006 |
Malignant neoplasm of prostate
|
0.350 |
Biomarker
|
disease |
BEFREE |
GREB1 is expressed in proliferating prostatic tissue and prostate cancer, is regulated by androgens, and suppression of GREB1 blocks androgen-induced growth suggesting GREB1 may be critically involved in prostate cancer proliferation.
|
16496412 |
2006 |
Prostatic Neoplasms
|
0.310 |
Biomarker
|
group |
CTD_human |
GREB1 is a novel androgen-regulated gene required for prostate cancer growth.
|
16496412 |
2006 |
Prostatic Neoplasms
|
0.310 |
AlteredExpression
|
group |
LHGDN |
GREB1 is a novel androgen-regulated gene required for prostate cancer growth.
|
16496412 |
2006 |
Endometrioma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genome-wide association meta-analysis identifies new endometriosis risk loci.
|
23104006 |
2012 |
Uterine Fibroids
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
Age at menarche
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
Plexiform leiomyoma
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis.
|
31649266 |
2019 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
GREB1 isoforms regulate proliferation independent of ERα co-regulator activities in breast cancer.
|
29695586 |
2018 |
Malignant neoplasm of breast
|
0.100 |
Biomarker
|
disease |
BEFREE |
GREB1 also ensured proper cellular reactions to different ligands by recruiting distinct sets of ERα cofactors to <i>cis</i>-regulatory elements, which explains the contradictory biological effects of GREB1 on breast cancer cell growth in response to estrogen or antiestrogen.
|
29212856 |
2018 |
Malignant neoplasm of breast
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Five variants were previously reported to confer risk of various malignant or benign tumors (rs78378222 in TP53, rs10069690 in TERT, rs1800057 and rs1801516 in ATM, and rs7907606 at OBFC1) and four signals are located at established risk loci for hormone-related traits (endometriosis and breast cancer) at 1q36.12 (CDC42/WNT4), 2p25.1 (GREB1), 20p12.3 (MCM8), and 6q26.2 (SYNE1/ESR1).
|
30194396 |
2018 |