|
Abnormality of the aryepiglottic fold
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abnormality of the voice
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acquired clubfoot
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice.
|
9449664 |
1998 |
|
Acrofacial Dysostosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations in several other genes involved in spliceosomal function or linked aspects of mRNA processing have also recently been identified in human disorders with specific craniofacial malformations: SF3B4 in Nager syndrome, an acrofacial dysostosis (AFD); SNRPB in cerebrocostomandibular syndrome, characterized by Robin sequence and rib defects; EIF4A3 in the AFD Richieri-Costa-Pereira syndrome, characterized by Robin sequence, median mandibular cleft and limb defects; and TXNL4A in Burn-McKeown syndrome, involving specific craniofacial dysmorphisms.
|
25865758 |
2015 |
|
Agenesis of mandibular central incisor
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Aplasia of the epiglottis
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Bifid uvula
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Burn-Mckeown syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mutations in several other genes involved in spliceosomal function or linked aspects of mRNA processing have also recently been identified in human disorders with specific craniofacial malformations: SF3B4 in Nager syndrome, an acrofacial dysostosis (AFD); SNRPB in cerebrocostomandibular syndrome, characterized by Robin sequence and rib defects; EIF4A3 in the AFD Richieri-Costa-Pereira syndrome, characterized by Robin sequence, median mandibular cleft and limb defects; and TXNL4A in Burn-McKeown syndrome, involving specific craniofacial dysmorphisms.
|
25865758 |
2015 |
|
Byzanthine arch palate
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
In this review, we discuss extensively the tumor-suppressive (for example, LINC00271, MEG3, NAMA, PTCSC1/2/3, etc.) and oncogenic (for example, ANRIL, FAL1, H19, PVT1, etc.) roles of various lncRNAs and their possible disease associations implicated in thyroid carcinogenesis.
|
29146581 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
FAL1 may promote tumorigenesis and progression of NSCLC through the PTEN/AKT axis, which could lead to lncRNA-related diagnostics and therapeutics in NSCLC.
|
28854421 |
2017 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis.
|
30470262 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Recently, investigations have focused on EIF4A3 dysfunction in carcinogenesis.
|
30588240 |
2018 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
Taken together, our findings underscore the crucial roles of lncRNA FAL1 in CRC carcinogenesis and its potential prognostic and therapeutic value.
|
30267804 |
2019 |
|
Carcinogenesis
|
0.060 |
Biomarker
|
phenotype |
BEFREE |
This study aims to elucidate the regulatory effect of long non-coding RNA (lncRNA) FAL1 on the tumorigenesis of oral squamous cell carcinoma (OSCC), and to explore its underlying mechanism.
|
31298329 |
2019 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Three proteins were uniquely altered in vaginal carcinoma (DDX48, erbB3-binding protein and biliverdin reductase) and five in cervical carcinoma (peroxiredoxin 2, annexin A2, sarcomeric tropomyosin kappa, human ribonuclease inhibitor and prolyl-4-hydrolase beta).
|
19367286 |
2009 |
|
Childhood Osteosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
LncRNA FAL1 is a negative prognostic biomarker and exhibits pro-oncogenic function in osteosarcoma.
|
29987852 |
2018 |
|
Cleft lower alveolar ridge
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Cleft mandible
|
0.400 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice.
|
9449664 |
1998 |
|
Cleft mandible
|
0.400 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Cleft Palate
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Richieri-Costa-Pereira syndrome: Expanding its phenotypic and genotypic spectrum.
|
29112243 |
2018 |
|
Clinodactyly of the 5th finger
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Here, we firstly report that the lncRNA H19 recruits eIF4A3 and promotes the CRC cell proliferation.
|
26989025 |
2016 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
LncRNA FAL1 promotes carcinogenesis by regulation of miR-637/NUPR1 pathway in colorectal cancer.
|
30267804 |
2019 |
|
Congenital Abnormality
|
0.010 |
Biomarker
|
group |
BEFREE |
Mutations in several other genes involved in spliceosomal function or linked aspects of mRNA processing have also recently been identified in human disorders with specific craniofacial malformations: SF3B4 in Nager syndrome, an acrofacial dysostosis (AFD); SNRPB in cerebrocostomandibular syndrome, characterized by Robin sequence and rib defects; EIF4A3 in the AFD Richieri-Costa-Pereira syndrome, characterized by Robin sequence, median mandibular cleft and limb defects; and TXNL4A in Burn-McKeown syndrome, involving specific craniofacial dysmorphisms.
|
25865758 |
2015 |