CDK1, cyclin dependent kinase 1, 983

N. diseases: 214; N. variants: 8
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.020 AlteredExpression disease BEFREE <b>Conclusions:</b> PAX2, though influencing the expression of CDK1, promotes the proliferation, enhances the mobility of endometrial cancer cells, thus exerts an important role in the carcinogenesis of endometrial cancer. 30405846 2018
CUI: C0007103
Disease: Malignant neoplasm of endometrium
Malignant neoplasm of endometrium 		0.010 AlteredExpression disease BEFREE <b>Conclusions:</b> PAX2, though influencing the expression of CDK1, promotes the proliferation, enhances the mobility of endometrial cancer cells, thus exerts an important role in the carcinogenesis of endometrial cancer. 30405846 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.100 AlteredExpression phenotype BEFREE <b>Conclusions:</b> PAX2, though influencing the expression of CDK1, promotes the proliferation, enhances the mobility of endometrial cancer cells, thus exerts an important role in the carcinogenesis of endometrial cancer. 30405846 2018
CUI: C0151449
Disease: Primary Sjögren's syndrome
Primary Sjögren's syndrome 		0.010 AlteredExpression disease BEFREE <b>Conclusions:</b> The decreased expression of miR-130a and miR-708 in pSS cDC2s seems to reflect cell activation. miR-130a targets MSK1, which regulates pro-inflammatory cytokine production, and we provide proof-of-concept for MSK1-inhibition as a therapeutic avenue to impede cDC2 activity in pSS. 31281310 2019
CUI: C1698088
Disease: Malignant Solid Neoplasm
Malignant Solid Neoplasm 		0.010 Biomarker disease BEFREE <b>Rationale:</b> Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein CDK1/PDK1/β-Catenin is activated, suggesting that inhibition of this pathway may have therapeutic potential. 30083256 2018
CUI: C4688336
Disease: Childhood Malignant Solid Neoplasm
Childhood Malignant Solid Neoplasm 		0.010 Biomarker disease BEFREE <b>Rationale:</b> Hepatocellular carcinoma (HCC) is an aggressive malignant solid tumor wherein CDK1/PDK1/β-Catenin is activated, suggesting that inhibition of this pathway may have therapeutic potential. 30083256 2018
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.600 Biomarker disease BEFREE <b>Results:</b> We found that CDK1 was frequently augmented in up to 46% (18/39) of HCC tissues, which was significantly associated with poor overall survival (p=0.008). 30083256 2018
CUI: C0002893
Disease: Refractory anemias
Refractory anemias 		0.010 Biomarker disease BEFREE RA treatment leads to Rb2 hyperphosphorylation, and p34(cdc2) kinase activation is coincident with an aberrant mitotic progression, followed by appearance of abnormal nucleus. 10094816 1999
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.010 Biomarker disease BEFREE RA treatment leads to Rb2 hyperphosphorylation, and p34(cdc2) kinase activation is coincident with an aberrant mitotic progression, followed by appearance of abnormal nucleus. 10094816 1999
CUI: C0023418
Disease: leukemia
leukemia 		0.050 AlteredExpression disease BEFREE Leukemias with a -5/del(5q) have a higher expression of genes involved in cell cycle control (CCNA2, CCNE2, CDC2), checkpoints (BUB1), or growth (MYC), and loss of expression of the gene encoding IFN consensus sequence-binding protein (ICSBP). 12417757 2002
CUI: C0019348
Disease: Herpes Simplex Infections
Herpes Simplex Infections 		0.030 Biomarker group BEFREE Herpes simplex virus 1 activates cdc2 to recruit topoisomerase II alpha for post-DNA synthesis expression of late genes. 12665617 2003
CUI: C0236734
Disease: Caffeine related disorders
Caffeine related disorders 		0.010 PosttranslationalModification group BEFREE Caffeine induced G(2)/M phase cell cycle arrest in NB4 cells in association with the induction of phosphorylation at the Ser-15 residue of p53 and induction of tyrosine phosphorylation of cdc2. 12811820 2003
CUI: C0023418
Disease: leukemia
leukemia 		0.050 AlteredExpression disease BEFREE Leukemias with a -5/del(5q) have a higher expression of genes involved in cell cycle control (CCNA2, CCNE2, CDC2), checkpoints (BUB1), or growth (MYC), and loss of expression of the gene encoding interferon consensus sequence-binding protein (ICSBP). 15935816 2005
CUI: C0019163
Disease: Hepatitis B
Hepatitis B 		0.020 AlteredExpression disease BEFREE Hepatitis B virus X protein (HBx) induces G2/M arrest and apoptosis through sustained activation of cyclin B1-CDK1 kinase. 19787227 2009
CUI: C2363741
Disease: HIV-1 infection
HIV-1 infection 		0.010 Biomarker disease BEFREE Cdk1 inhibition prevents the death of syncytia elicited by HIV-1 infection of primary CD4 lymphoblasts. 12145207 2002
CUI: C0205768
Disease: Subependymal Giant Cell Astrocytoma
Subependymal Giant Cell Astrocytoma 		0.010 AlteredExpression disease BEFREE p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. 12731003 2003
CUI: C1832033
Disease: Adult Subependymal Giant Cell Astrocytoma
Adult Subependymal Giant Cell Astrocytoma 		0.010 AlteredExpression disease BEFREE p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. 12731003 2003
CUI: C1832034
Disease: Childhood Subependymal Giant Cell Astrocytoma
Childhood Subependymal Giant Cell Astrocytoma 		0.010 AlteredExpression disease BEFREE p34cdc2, collapsin response mediator protein 4 (CRMP4), doublecortin (DCX), HuD, and NeuN expression was assessed in tuber (n = 16) and subependymal giant cell astrocytoma (SEGA; n = 6) specimens in tuberous sclerosis complex to define the developmental phenotype and lineage of giant cells (CGs) in these lesions. 12731003 2003
CUI: C0279628
Disease: Adenocarcinoma Of Esophagus
Adenocarcinoma Of Esophagus 		0.010 AlteredExpression disease BEFREE CDC2/CDK1 expression in esophageal adenocarcinoma and precursor lesions serves as a diagnostic and cancer progression marker and potential novel drug target. 15725809 2005
CUI: C0333463
Disease: Senile Plaques
Senile Plaques 		0.010 GeneticVariation disease BEFREE CDC2 genotypes were evaluated in relation to CSF protein levels of total tau, phospho-tau and beta-amyloid(1-42) in AD patients and control individuals, and in relation to the amount of senile plaques and NFT in the frontal cortex and in the hippocampus in patients with autopsy-proven AD and controls. 16192727 2005
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.090 Biomarker disease BEFREE Cdc2 and cyclin B1 might be responsible for the different responses of glioblastoma cell lines to GA. 17324379 2007
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.090 Biomarker disease BEFREE Cdc2 and cyclin B1 might be responsible for the different responses of glioblastoma cell lines to GA. 17324379 2007
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 Biomarker disease BEFREE Cdc2 and cyclin B1 might be responsible for the different responses of glioblastoma cell lines to GA. 17324379 2007
CUI: C0280474
Disease: Childhood Glioblastoma
Childhood Glioblastoma 		0.060 Biomarker disease BEFREE Cdc2 and cyclin B1 might be responsible for the different responses of glioblastoma cell lines to GA. 17324379 2007
CUI: C0024299
Disease: Lymphoma
Lymphoma 		0.020 Biomarker group BEFREE CDK1 inhibitor treatment of MYC-dependent mouse lymphoma and hepatoblastoma tumors decreased tumor growth and prolonged their survival. 17589519 2007