CDK1, cyclin dependent kinase 1, 983

N. diseases: 214; N. variants: 8
Disease: Hepatoblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.220 Biomarker disease BEFREE Calycopterin treatment also affected HepG2 cell viability: (a) by inhibiting cell cycle progression at the G2/M transition leading to growth arrest and apoptosis; (b) by decreasing the expression of mitotic kinase cdc2, mitotic phosphatase cdc25c, mitotic cyclin B1, and apoptotic factors pro-caspases-3 and -9; and (c) increasing the levels of mitochondrial apoptotic-related proteins, intracellular levels of reactive oxygen species, and nitric oxide. 25060910 2014
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.220 Biomarker disease RGD Forkhead box M1B is a determinant of rat susceptibility to hepatocarcinogenesis and sustains ERK activity in human HCC. 19136513 2009
CUI: C0206624
Disease: Hepatoblastoma
Hepatoblastoma 		0.220 Biomarker disease BEFREE CDK1 inhibitor treatment of MYC-dependent mouse lymphoma and hepatoblastoma tumors decreased tumor growth and prolonged their survival. 17589519 2007