CDK1, cyclin dependent kinase 1, 983

N. diseases: 214; N. variants: 8
Disease: Adult Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 Biomarker disease BEFREE We further show that inhibition of the splicing regulatory cdc2-like kinases in combination with an ERR-β agonist shifts isoform expression in favor of ERR-β2 and potentiates inhibition of growth and migration in GBM cells and intracranial tumors.-Tiek, D. M., Khatib, S. A., Trepicchio, C. J., Heckler, M. M., Divekar, S. D., Sarkaria, J. N., Glasgow, E., Riggins, R. B. Estrogen-related receptor β activation and isoform shifting by cdc2-like kinase inhibition restricts migration and intracranial tumor growth in glioblastoma. 31570001 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 Biomarker disease BEFREE Tie2-FGFR1 Interaction Induces Adaptive PI3K Inhibitor Resistance by Upregulating Aurora A/PLK1/CDK1 Signaling in Glioblastoma. 31416846 2019
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 Biomarker disease BEFREE Cdc2-like kinase 2 is a key regulator of the cell cycle via FOXO3a/p27 in glioblastoma. 27050366 2016
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 AlteredExpression disease BEFREE Expression of CDC2 was evaluated in glioblastoma and cell lines by immunohistochemistry and Western blot analysis. 25433945 2015
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 Biomarker disease BEFREE Cdc2 and cyclin B1 might be responsible for the different responses of glioblastoma cell lines to GA. 17324379 2007
CUI: C0278878
Disease: Adult Glioblastoma
Adult Glioblastoma 		0.060 Biomarker disease BEFREE Growth inhibition induced by Ro 31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. 9858877 1998