CDC25A, cell division cycle 25A, 993

N. diseases: 105; N. variants: 2
Disease: Squamous cell carcinoma of the head and neck ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.030 Biomarker disease BEFREE Preferential allelic deletion of RBSP3, LIMD1 and CDC25A in head and neck squamous cell carcinoma: Implication in cancer screening and early detection. 29624473 2018
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.030 AlteredExpression disease BEFREE SKLB188 inhibited HNSCC cell proliferation by inducing G<sub>1</sub> cell cycle arrest, which was associated with downregulating the expression of Cdc25A, cyclins D1/A and cyclin-dependent kinases (CDK2/4), and upregulating the expression of cyclin-dependent kinase (CDK) inhibitors (p21<sup>Cip1</sup> and p27<sup>Kip1</sup>), leading to decreased phosphorylation of Rb. 28873083 2017
CUI: C1168401
Disease: Squamous cell carcinoma of the head and neck
Squamous cell carcinoma of the head and neck 		0.030 GeneticVariation disease BEFREE On the other hand, frequent alterations (deletion/methylation) of SH3GL2 (63-77%) and CDC25A (37-64%) were seen in the dysplastic and HNSCC samples. 23675485 2013