Chronic cholecystitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Significantly higher frequencies of methylation in GBC compared with CC were detected for eight genes (3-OST-2, CDH13, CDH1, RUNX3, APC, RIZ1, P16INK4A, and HPP1).
|
15447999 |
2004 |
Infection
|
0.010 |
Biomarker
|
group |
LHGDN |
A role for heparan sulfate 3-O-sulfotransferase isoform 2 in herpes simplex virus type 1 entry and spread.
|
16336986 |
2006 |
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
3-OST-2 followed by, RASSF1A showed increased levels of methylation with advanced tumor stage (P<0.05).
|
16644104 |
2007 |
Malignant tumor of cervix
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Our data support further evaluation of HS3ST2 and CDH1 methylation as potential markers of cervical cancer and its precursor lesions.
|
17894941 |
2007 |
Cervix carcinoma
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Our data support further evaluation of HS3ST2 and CDH1 methylation as potential markers of cervical cancer and its precursor lesions.
|
17894941 |
2007 |
cervical cancer
|
0.020 |
PosttranslationalModification
|
disease |
BEFREE |
Our data support further evaluation of HS3ST2 and CDH1 methylation as potential markers of cervical cancer and its precursor lesions.
|
17894941 |
2007 |
Squamous cell carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Based on receiver operating characteristic (ROC) analysis, HS3ST2 was the most significant candidate in segregating HSIL/SCC from normal/LSIL cases (p<0.0001); at an optimal cutoff value, sensitivity and specificity between 70% and 80% were obtained.
|
20708786 |
2010 |
Colorectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer.
|
21187457 |
2010 |
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
Aberrant methylation of heparan sulfate glucosamine 3-O-sulfotransferase 2 genes as a biomarker in colorectal cancer.
|
21187457 |
2010 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Data from lymphoma and colorectal cancer samples for SNRPN (imprinted gene), FGF6 (demethylated in the cancer samples) and HS3ST2 (methylated in the cancer samples) serve as a proof of principle showing the integration of SNP data and phased DNA-methylation information into "hepitypes" and thus the analysis of DNA methylation phylogeny in the somatic evolution of cancer.
|
21750708 |
2011 |
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
Data from lymphoma and colorectal cancer samples for SNRPN (imprinted gene), FGF6 (demethylated in the cancer samples) and HS3ST2 (methylated in the cancer samples) serve as a proof of principle showing the integration of SNP data and phased DNA-methylation information into "hepitypes" and thus the analysis of DNA methylation phylogeny in the somatic evolution of cancer.
|
21750708 |
2011 |
Lymphoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Data from lymphoma and colorectal cancer samples for SNRPN (imprinted gene), FGF6 (demethylated in the cancer samples) and HS3ST2 (methylated in the cancer samples) serve as a proof of principle showing the integration of SNP data and phased DNA-methylation information into "hepitypes" and thus the analysis of DNA methylation phylogeny in the somatic evolution of cancer.
|
21750708 |
2011 |
Adult Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data from lymphoma and colorectal cancer samples for SNRPN (imprinted gene), FGF6 (demethylated in the cancer samples) and HS3ST2 (methylated in the cancer samples) serve as a proof of principle showing the integration of SNP data and phased DNA-methylation information into "hepitypes" and thus the analysis of DNA methylation phylogeny in the somatic evolution of cancer.
|
21750708 |
2011 |
Childhood Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Data from lymphoma and colorectal cancer samples for SNRPN (imprinted gene), FGF6 (demethylated in the cancer samples) and HS3ST2 (methylated in the cancer samples) serve as a proof of principle showing the integration of SNP data and phased DNA-methylation information into "hepitypes" and thus the analysis of DNA methylation phylogeny in the somatic evolution of cancer.
|
21750708 |
2011 |
Leukemia, Myelocytic, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
An association between HS3ST2 and AML patients with favourable cytogenetic risk was identified (P = 0·0469).
|
22924777 |
2012 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Patients with HS3ST2 hypermethylation in 193 node-negative stage I-II NSCLCs with a median follow-up period of 5.8 years had poor overall survival (hazard ratio = 2.12, 95% confidence interval = 1.25-3.58, P = 0.005) compared to those without HS3ST2 hypermethylation, after adjusting for age, sex, tumor size, adjuvant therapy, recurrence, and differentiation.
|
24265783 |
2013 |
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
We evaluated the methylation status of four genes (TGFB2, SLIT2, HS3ST2, and TMEFF2) in biopsies of four groups of patients: 60 patients with sporadic CRC, 32 patients with IBD-associated neoplasia, 85 patients with IBD without associated neoplasia (20 at high risk and 65 at low risk), and 28 healthy controls.
|
22532293 |
2013 |
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with HS3ST2 hypermethylation in 193 node-negative stage I-II NSCLCs with a median follow-up period of 5.8 years had poor overall survival (hazard ratio = 2.12, 95% confidence interval = 1.25-3.58, P = 0.005) compared to those without HS3ST2 hypermethylation, after adjusting for age, sex, tumor size, adjuvant therapy, recurrence, and differentiation.
|
24265783 |
2013 |
Malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Exogenous expression of HS3ST2 in lung cancer cells H460 and H23 inhibited cell migration, invasion, cell proliferation and whereas knockdown of HS3ST2 in NHBE cells induced cell migration, invasion, and cell proliferation in vitro.
|
24265783 |
2013 |
Carcinogenesis
|
0.010 |
PosttranslationalModification
|
phenotype |
BEFREE |
Epigenetic inactivation of heparan sulfate (glucosamine) 3-O-sulfotransferase 2 in lung cancer and its role in tumorigenesis.
|
24265783 |
2013 |
Carcinoma of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Exogenous expression of HS3ST2 in lung cancer cells H460 and H23 inhibited cell migration, invasion, cell proliferation and whereas knockdown of HS3ST2 in NHBE cells induced cell migration, invasion, and cell proliferation in vitro.
|
24265783 |
2013 |
Primary malignant neoplasm of lung
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Exogenous expression of HS3ST2 in lung cancer cells H460 and H23 inhibited cell migration, invasion, cell proliferation and whereas knockdown of HS3ST2 in NHBE cells induced cell migration, invasion, and cell proliferation in vitro.
|
24265783 |
2013 |
Malignant neoplasm of breast
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study provides the first in vitro evidence of the involvement of HS3ST2 in breast cancer cell invasion and chemosensitivity.
|
24752740 |
2014 |
Breast Carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
This study provides the first in vitro evidence of the involvement of HS3ST2 in breast cancer cell invasion and chemosensitivity.
|
24752740 |
2014 |
Malignant tumor of cervix
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results indicate that HS3ST2 and CCNA1 genes may play important roles in HPV-induced cervical cancer and that patients with specific hypermethylated genes may have a greater risk of progressing to invasive cervical cancer.
|
25198553 |
2014 |