|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Additionally, the loss of USP3 was associated with distal metastasis and a poor prognosis.
|
28655924 |
2017 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Moreover, xenograft proliferation and metastasis were used to explore the influence of USP3 on tumor growth and metastasis in animals.
|
30168892 |
2018 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
However, the mechanism by which USP3 promotes gastric cancer (GC) metastasis remains largely unknown.
|
31234902 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Ectopic expression of Snail could largely rescue the inhibitory effects of USP3 depletion on migration, invasion, and tumor growth of GBM cells.
|
31266817 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Moreover, xenograft proliferation and metastasis were used to explore the influence of USP3 on tumor growth and metastasis in animals.
|
30168892 |
2018 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Effects of USP3 on the progression of GC in vivo and in vitro and the potential underlying mechanisms have been investigated utilizing proteomics, RT-PCR, western blotting, immunohistochemistry, immunofluorescence, cell invasion and migration assays and xenograft tumor models.
|
31234902 |
2019 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We measured USP3 expression in normal and GC tissues and cell lines.
|
30168892 |
2018 |
|
Malignant neoplasm of stomach
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we found that SUZ12 is indispensable for USP3-mediated oncogenic activity in GC.
|
31234902 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
USP3 knockdown inhibits breast cancer cell proliferation <i>in vitro</i> and tumorigenesis <i>in vivo</i>, which can be partially rescued by ectopic expression of KLF5.
|
31624151 |
2019 |
|
Carcinogenesis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
The present study explored the involvement of USP3 in the carcinogenesis and prognosis of GC.
|
30168892 |
2018 |
|
Stomach Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we found that SUZ12 is indispensable for USP3-mediated oncogenic activity in GC.
|
31234902 |
2019 |
|
Stomach Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We measured USP3 expression in normal and GC tissues and cell lines.
|
30168892 |
2018 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Overall, our findings reveal a critical USP3-Snail signaling axis in EMT and invasion, and provide an effective therapeutic approach against GBM.
|
31266817 |
2019 |
|
Tumor Cell Invasion
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Effects of USP3 on the progression of GC in vivo and in vitro and the potential underlying mechanisms have been investigated utilizing proteomics, RT-PCR, western blotting, immunohistochemistry, immunofluorescence, cell invasion and migration assays and xenograft tumor models.
|
31234902 |
2019 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that USP3 is a new KLF5 deubiquitinase and that USP3 may represent a potential therapeutic target for breast cancer.
|
31624151 |
2019 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To date, expression of ubiquitin-specific protease 3 (USP3) in all types of cancer, including GC, is still unknown.
|
30168892 |
2018 |
|
Colorectal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer.
|
28655924 |
2017 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
IMPLICATIONS: Our study establishes USP3-mediated Snail stabilization as an important mechanism underlying GBM invasion and progression, and provides a rationale for potential therapeutic interventions in the treatment of GBM.
|
31266817 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, these data support the pursuit of USP3 and TRAF6 as potential targets for osteoarthritis therapies.
|
31056254 |
2019 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that RUL UBP ECT is safe, feasible, and potentially efficacious in treating multiple domains of PD, including motor and mood, without clear cognitive side effects.
|
27241213 |
2017 |
|
Seizures
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
This case illustrates that, along with other augmentation strategies, RUL-UBP ECT represents an alternative for seizure induction in clinical practice.
|
29503544 |
2018 |
|
Tumor Progression
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The USP3-SUZ12 axis might promote tumor progression and could be a potential therapeutic candidate for human GC.
|
31234902 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail.
|
31266817 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Ubiquitin-Specific Protease 3 Promotes Glioblastoma Cell Invasion and Epithelial-Mesenchymal Transition via Stabilizing Snail.
|
31266817 |
2019 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings suggest that USP3 is a new KLF5 deubiquitinase and that USP3 may represent a potential therapeutic target for breast cancer.
|
31624151 |
2019 |