Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.330 Biomarker disease BEFREE TFA of Aroclor 1260 treatment demonstrated alterations in the function of 42 transcription factors including downregulation of NRF2 and key nuclear receptors previously demonstrated to protect against steatohepatitis (e.g., HNF4α, FXR, PPARα/δ/γ, etc.). 30807179 2019
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.330 Biomarker disease BEFREE In the subsequent network analysis, we have identified three major upstream regulators - Hnf4a, Ppara and Nr1h4 and liver steatosis (p=0.0001) and liver necrosis/cell death (apoptosis of liver cells, p=0.0003) among the most enriched Tox categories. 30484681 2018
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.330 Biomarker disease BEFREE G-protein-coupled bile acid receptor plays a key role in bile acid metabolism and fasting-induced hepatic steatosis in mice. 27351453 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis
0.330 Biomarker disease CTD_human Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling. 29142166 2017