Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Kras activation and Pten deletion are observed in intestinal-type gastric cancer, and Cdh1 mutation is associated with diffuse-type gastric cancer.
|
30168144 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The -472delA (rs5030625) and -160C>A (rs16260) polymorphisms in CDH1 induce a decrease in gene transcription; in fact, these mutated alleles have been associated with GC in some populations, with conflicting results.
|
27706737 |
2016 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Gastric cancer (GC) is considered to be one of the leading cancers in East Asians, and mutations in the CDH1 gene and the reduced expression of E-cadherin are the most frequent genetic alterations in gastric cancer.
|
23435907 |
2013 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Familial diffuse type gastric cancer occurs due to germ-line mutations of the CDH1 gene.
|
16273224 |
2005 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
The poorly cohesive histology/CDH1-mutant GC subgroup showed the worst survival (p < 0.001).
|
30801717 |
2019 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Inactivation of the E-cadherin gene in sporadic diffuse-type gastric cancer.
|
11598162 |
2001 |
Malignant neoplasm of stomach
|
0.800 |
Biomarker
|
disease |
BEFREE |
A great number of genes with promoter methylation have been observed in gastric cancer (GC), among which p16INK4A (p16), Mut L homologue 1 (MLH1), Epithelial-cadherin (E-cadherin), Runt-related transcription factor 3 (RUNX3), adenomatous polyposis coli (APC), O(6)-methylguanine-DNA methyltransferase (MGMT), Ras association domain family 1A (RASSF1A) and Death-associated protein kinase (DAPK) have been extensively studied.
|
22936446 |
2012 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Analysis of HDGC patients harbouring CDH1 alleles with PTCs at a wide variety of different positions indicates an association of their predicted ability to induce NMD and an earlier age of onset of gastric cancer.
|
18427545 |
2008 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
No associations between CDH1 (+54T>C, -160C>A, -347G>GA, -616G>C, -2076C>T and -3159T>C) gene polymorphisms and GC risk for all genetic models were found.
|
21570316 |
2011 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We have shown that germline CDH1 mutations are associated with early onset of bilateral LCIS with or without ILC in women without a family history of gastric cancer.
|
24366306 |
2014 |
Malignant neoplasm of stomach
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
CDH1 gene promoter hypermethylation in gastric cancer: relationship to Goseki grading, microsatellite instability status, and EBV invasion.
|
16531765 |
2006 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
All individuals with a CDH1 mutation had a personal or family history of diffuse gastric cancer.
|
26072394 |
2015 |
Malignant neoplasm of stomach
|
0.800 |
PosttranslationalModification
|
disease |
BEFREE |
E-cadherin promoter hypermethylation induced by interleukin-1beta treatment or H. pylori infection in human gastric cancer cell lines.
|
18249489 |
2008 |
Malignant neoplasm of stomach
|
0.800 |
Biomarker
|
disease |
BEFREE |
CDH1 associated gastric cancer: a report of a family and review of the literature.
|
15780560 |
2005 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Hereditary diffuse gastric cancer is caused by germline mutations in the epithelial cadherin (CDH1) gene and is characterized by an increased risk for diffuse gastric cancer and lobular breast cancer.
|
17545690 |
2007 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
In our area, in which a high rate of familial aggregation was demonstrated, the lack of germ line mutation of TP53 together with the infrequency of mutation of E-cadherin gene seem to limit the role of genetic predisposition in the development of gastric cancer.
|
19674071 |
2010 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, the CDH1 c.1679C>G (p.T560R) variant segregated with gastric cancer in all three family members affected with gastric cancer in this family.
|
27880784 |
2016 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
CIHM of CDH1 and DAP-kinase in non-neoplastic gastric mucosa corresponded to a risk of GC regardless of histological subtype, H. pylori infection status, gender and generation.
|
20150736 |
2010 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
We screened all exons of the E-cadherin gene for mutations in 101 Japanese patients having an intense family history of gastric cancers.
|
12604719 |
2003 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Endoscopic Ultrasound Has Limited Utility in Diagnosis of Gastric Cancer in Carriers of CDH1 Mutations.
|
31077828 |
2020 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Using polymerase chain reaction (PCR)/single-strand conformation polymorphism (SSCP)/sequencing, we screened 32 Portuguese families with a history of gastric cancer and 23 patients with early onset gastric cancer for CDH1 germline mutations.
|
15288293 |
2004 |
Malignant neoplasm of stomach
|
0.800 |
AlteredExpression
|
disease |
BEFREE |
The E-cadherin protein expression level in gastric cancer tissues was significantly lower than that in the adjacent normal tissues (p < 0.05).
|
22581441 |
2012 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
Overall, 78% of GC cases harbored one clinically relevant GA or more, with the most frequent alterations being found in TP53 (50%), ARID1A (24%), KRAS (16%), CDH1 (15%), CDKN2A (14%), CCND1 (9.5%), ERBB2 (8.5%), PIK3CA (8.6%), MLL2 (6.9%), FGFR2 (6.0%), and MET (6.0%).
|
25882375 |
2015 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
CDH1 germ-line missense mutation identified by multigene sequencing in a family with no history of diffuse gastric cancer.
|
25981591 |
2015 |
Malignant neoplasm of stomach
|
0.800 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the ATCTG and CTTTG CDH1 haplotypes may be associated with an increased risk and decreased risk, respectively, of GC in the Japanese population.
|
17852867 |
2007 |