Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CLINGEN Expression of E- and P-cadherin in gastric carcinomas. 2009537 1991
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CLINGEN Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. 2070412 1991
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 CausalMutation disease CLINVAR Localization of specificity determining sites in cadherin cell adhesion molecules. 2317870 1990
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease CLINVAR E-cadherin gene mutations in human gastric carcinoma cell lines. 8127895 1994
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CLINGEN From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion. 8236461 1993
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CLINGEN A causal role for E-cadherin in the transition from adenoma to carcinoma. 9515965 1998
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CTD_human E-cadherin germline mutations in familial gastric cancer. 9537325 1998
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CLINGEN E-cadherin germline mutations in familial gastric cancer. 9537325 1998
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease CLINVAR E-cadherin germline mutations in familial gastric cancer. 9537325 1998
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 CausalMutation disease CLINVAR Identification of germ-line E-cadherin mutations in gastric cancer families of European origin. 9751616 1998
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease CLINVAR Coupling assembly of the E-cadherin/beta-catenin complex to efficient endoplasmic reticulum exit and basal-lateral membrane targeting of E-cadherin in polarized MDCK cells. 10037790 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 CausalMutation disease CLINVAR We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CTD_human We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 Biomarker disease CLINGEN We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease BEFREE We have confirmed that germline mutations in the CDH1 gene cause familial gastric cancer in non-Maori populations. 10072428 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 CausalMutation disease CLINVAR Identification of eleven novel tumor-associated E-cadherin mutations. Mutations in brief no. 215. Online. 10094558 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease UNIPROT We screened five Korean familial gastric cancer patients to investigate germline mutations of the E-cadherin gene. 10319582 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease BEFREE However, no germ-line mutation was detected, suggesting that a predisposition to FGCs by E-cadherin gene mutation is infrequent in Japanese cases. 10389930 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 CausalMutation disease CLINVAR Diffuse type gastric and lobular breast carcinoma in a familial gastric cancer patient with an E-cadherin germline mutation. 10433926 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 CausalMutation disease CLINVAR E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. 10477433 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease CLINVAR E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer. 10477433 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease BEFREE These results demonstrate that germline mutation of the E-cadherin gene is a common cause of hereditary diffuse gastric cancer and suggest a role for these mutations in the incidence of breast cancer. 10477433 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 GeneticVariation disease BEFREE More recently, germline E-cadherin/CDH1 mutations have been identified in hereditary diffuse gastric cancer kindred. 10593993 1999
CUI: C1708349
Disease: Hereditary Diffuse Gastric Cancer
Hereditary Diffuse Gastric Cancer
0.800 PosttranslationalModification disease BEFREE Methylation of the CDH1 promoter as the second genetic hit in hereditary diffuse gastric cancer. 10973239 2000