Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association of familial colorectal cancer with variants in the E-cadherin (CDH1) and cyclin D1 (CCND1) genes.
|
17960397 |
2008 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
The influence of CEA production by colorectal cancer cells on the function of E-cadherin junction complexes may explain the link between the elevated levels of CEA and the increase in soluble E-cadherin during the progression of colorectal cancer.
|
24726916 |
2014 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Consolidated results of the fluorescency of all of the differential genes, designated two coding E-cadherin (CDH1) with the lower expression, and P-cadherin (CDH3) with higher expression in CRC tissue.
|
26167814 |
2015 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether E-cadherin gene (CDH1) mutations occur in colorectal cancer, we screened 49 human colon carcinoma cell lines from 43 patients by single-strand conformation polymorphism (SSCP) analysis and direct sequencing.
|
10051639 |
1999 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Hypermethylation of the E-cadherin gene (CDH1) has not been described previously in colorectal cancer.
|
11171827 |
2001 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Human CRC patient microarray data revealed that the expression of PHLPP1 or PHLPP2 is positively correlated with CDH1.
|
24530606 |
2014 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
With respect to cadherin 1 (CDH1) and fibroblast growth factor receptor 2 (FGFR2), the mutational rates for non-neoplastic colorectal mucosa were similar to those in sporadic CRC.
|
28871001 |
2018 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In one family there was evidence of non-penetrance and susceptibility to both gastric and colorectal cancer; thus, in addition to six cases of gastric cancer, a CDH1 mutation carrier developed colorectal cancer at age 30 years.
|
10072428 |
1999 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Comprehensive analysis of colorectal cancer-risk loci and survival outcome: A prognostic role for CDH1 variants.
|
31734605 |
2020 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In addition, to better understand the role of CCND1 and CDH1 in the pathophysiology of CRC, the expression pattern was evaluated in analogous tumor and adjacent normal tissues from 23 CRC patients by Western blot analysis.
|
25146682 |
2014 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Decreased E-cadherin protein expression in CRCs was an independent poor prognostic factor in multivariate disease-free survival analysis.
|
18503162 |
2008 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Following GWAS and candidate studies evaluated the association between the CDH1 rs9929218 polymorphism and CRC in European, Asian and American populations.
|
27259261 |
2016 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
We identified four previously unreported CRC risk loci at 14q22.2 (rs4444235, BMP4; P = 8.1 x 10(-10)), 16q22.1 (rs9929218, CDH1; P = 1.2 x 10(-8)), 19q13.1 (rs10411210, RHPN2; P = 4.6 x 10(-9)) and 20p12.3 (rs961253; P = 2.0 x 10(-10)).
|
19011631 |
2008 |
Colorectal Carcinoma
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
A further subgroup analysis by type of control tissues suggested that CRC tissues also exhibited higher frequencies of CDH1 promoter methylation than those of normal and adjacent tissues (normal: OR=1.57, 95% CI=1.12-2.21, p=0.009; adjacent: OR=5.07, 95% CI=2.91-8.82, p<0.001; respectively).
|
24684676 |
2014 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Loss of CDH1 expression in colorectal cancer is associated with infiltrative tumour growth pattern and lymph node metastasis.
|
26742007 |
2016 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated the contribution of polymorphisms in two genes implicated in the pathogenesis of colorectal cancer, cyclin D1 (CCND1) and E-cadherin (CDH1), to familial and sporadic forms of the disease.
|
11896626 |
2002 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
For this reason, methylation of the CDH1 promoter is an attractive new biomarker for detecting ulcerative colitis patients with a high risk for developing colorectal cancers.
|
12203775 |
2002 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The -160C/A CDH1, -1607ins/delG MMP-1 and -181A/G MMP-7 single nucleotide polymorphisms did not modify the risk of CRC development.
|
19634113 |
2009 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Absent or decreased E-cadherin protein expression was found in 27 (38%) of 68 colorectal cancers and the pattern of expression did not differ significantly among the three tumour groups.
|
9203946 |
1997 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings highlight the importance of genetic testing for MMR gene mutations in children with colorectal cancer and suggest further investigation into the prognostic role of E-cadherin in pediatric CRAC.
|
21985494 |
2012 |
Colorectal Carcinoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated the methylation status in the promoter regions of the RARβ2, RASSF1A, DAPKinase, and CDH1 genes in 73 colorectal carcinoma and 43 paired normal tissues of Tunisian patients using methylation-specific PCR assays.
|
20571967 |
2010 |
Colorectal Carcinoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
MeCP2 and promoter methylation cooperatively regulate E-cadherin gene expression in colorectal carcinoma.
|
12824891 |
2003 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the CDH1 -160C/A polymorphism may be a susceptible predictor for the risk of CRC in Caucasians.
|
29283329 |
2017 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Breast and colorectal cancer have also been reported in CDH1-associated HDGC.
|
11729114 |
2001 |
Colorectal Carcinoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We evaluated ORs between location of truncating variants of CDH1 and incidence of colorectal cancer, breast cancer and cancer at young age (gastric cancer at <40 or breast cancer <50 years of age).
|
30745422 |
2019 |